Isolation and characterization of a group of oligopeptides related to   oxidized glutathione from the root of Panax ginseng

CORC > 北京大学 > 化学与分子工程学院

	Isolation and characterization of a group of oligopeptides related to oxidized glutathione from the root of Panax ginseng
	Chen, ZK ; Fan, CX ; Ye, YH ; Yang, L ; Jiang, Q ; Xing, QY
刊名	journal of peptide research
	1998
关键词	gamma-glutamylarginine N-gamma-glutamylcystinyl-bis-glycine N,N &apos N-gamma-glutamylglycylcysteine disulfide Panax ginseng oligopeptide glutathione oxidized glutathione CANCER CELLS -bis-gamma-glutamylcystinylglycine
英文摘要	Six gamma-glutamyl oligopeptides were isolated for the first time from aqueous methanol extracts of Panax ginseng root by using column chromatography on ion-exchange resin, gel filtration and reverse-phase high-performance liquid chromatography. Their structures had been established with the methods of amino acid analysis, N-terminal, C-terminal determination and double-coupling sequence analysis. They were: P-I (N-gamma-glutamylcystinyl-bis-glycine), P-II (gamma-glutamylcysteinylglycine disulfide, oxidized glutathione), P-III (N,N '-bis-gamma-glutamylcystinylylycine), P-IV (gamma-glutamylcysteinylglycinamide disulfide), P-V (N-gamma-glutamylglycylcysteine disulfide), P-VI (gamma-glutamylarginine); five of them are related to oxidized glutathione. The structures were further confirmed by the chemical synthesis. As far as we know, P-V (N-gamma-glutamylglycylcysteine disulfide) is a new biologically active peptide which exhibits somnogenic effect and is more potent than that of P-II.; Biochemical Research Methods; Biochemistry & Molecular Biology; SCI(E); 5; 2; 137-142; 52
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/390110]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Chen, ZK,Fan, CX,Ye, YH,et al. Isolation and characterization of a group of oligopeptides related to oxidized glutathione from the root of Panax ginseng[J]. journal of peptide research,1998.
APA	Chen, ZK,Fan, CX,Ye, YH,Yang, L,Jiang, Q,&Xing, QY.(1998).Isolation and characterization of a group of oligopeptides related to oxidized glutathione from the root of Panax ginseng.journal of peptide research.
MLA	Chen, ZK,et al."Isolation and characterization of a group of oligopeptides related to oxidized glutathione from the root of Panax ginseng".journal of peptide research (1998).