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	Gold nanoprobes for multi-modality tumor imaging
	Nyagilo, James ; Xiao, Ming ; Sun, Xiankai ; Dav??, Digant P.
	2010
英文摘要	Gold nanoparticles have been shown to possess x-ray attenuation higher than that of clinically used iodine based contrast agents. Additionally, gold nanoparticles have also been used in enhancing the Raman signal through a phenomenon called Surface Enhanced Raman Scattering (SERS). The development of Gold nanoparticle based probes (nanotags) for combined SERS and x-ray computed tomography (CT) are reported. These nanotags comprise quasi-spherical gold nanoparticles encoded using a Raman active molecule and encapsulated by a monolayer of polyethylene glycol with carboxylate functional groups for bioconjugation. The nanotags, made from ??65 nm gold nanoparticles, display large SERS cross-section and x-ray absorption which are used for dual modality imaging of tumor cells in of an orthotropic prostate cancer tumor animal model. ? 2010 Copyright SPIE - The International Society for Optical Engineering.; EI; 0
语种	英语
DOI标识	10.1117/12.842917
内容类型	其他
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/330217]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Nyagilo, James,Xiao, Ming,Sun, Xiankai,et al. Gold nanoprobes for multi-modality tumor imaging. 2010-01-01.

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