QQ客服 官方微博 反馈留言

	In situ polycondensation of amino acid modified liposomes and their properties
	Li, ZC ; He, W ; Li, FM
	1996
关键词	liposome amino acid condensation peptide permeability MEMBRANES
英文摘要	Three amphiphilic amino acids based on glutamic acid, i.e. S-[1-carboxy-2-([N-bistetradecyl-L-glutamate]carbonyl)ethyl]cysteine (1), S-[1-carboxy-2-([N-bishexadecyl-L-glutamate]carbonyl)ethyl]cysteine (2), S-[1-carboxy-2-([N-bisoctadecyl-L-glutamate]carbonyl)ethyl]cysteine (3), were synthesized. The aggregation behavior of them in water or buffer solution was studied. It was found that upon hydration and sonication in water, they could form stable liposomes. This kind of amino acid modified liposome was then polycondensed locally on the liposome surface to form a polypeptide-surfaced liposome and the peptide formation was detected by FT-IR, GPC, etc. The effect of polycondensation of amino acid on the properties of liposomes were studied by detecting the phase transition temperatures with DSC or measuring the leakage of the encapsulated fluorescent probe from the liposomes. It was observed that the phase transition temperatures of the peptide liposomes moved down and the polycondensation of amino acid moieties obviously increased the leakage of the encapsulated molecules.; Chemistry, Applied; Engineering, Chemical; Polymer Science; SCI(E); EI; 5
语种	英语
DOI标识	10.1016/1381-5148(95)00117-4
内容类型	其他
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/258398]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Li, ZC,He, W,Li, FM. In situ polycondensation of amino acid modified liposomes and their properties. 1996-01-01.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。