Distinguishing malignant from normal stomach tissues and its in vivo, in   situ measurement in operating process using FTIR Fiber-Optic techniques

doi:10.1360/04yb0135

CORC > 北京大学 > 化学与分子工程学院

	Distinguishing malignant from normal stomach tissues and its in vivo, in situ measurement in operating process using FTIR Fiber-Optic techniques
	Xu, YZ ; Yang, LM ; Xu, Z ; Zhao, Y ; Ling, XF ; Li, OB ; Wang, JS ; Zhang, NW ; Zhang, YF ; Wu, JG
刊名	中国科学b辑化学英文版
	2005
关键词	FTIR Fiber-Optics stomach tissues cancer diagnosis TRANSFORM INFRARED MICROSCOPY RAMAN-SPECTROSCOPY CANCER
DOI	10.1360/04yb0135
英文摘要	Gastric tissue samples were studied using mid-IR fiber-optic attenuated total reflectance (ATR) spectroscopy. FTIR spectra of 90 tissue samples from 48 patients, including 32 normal and 58 malignant tissue samples, were chosen as examples. Malignancy was usually characterized by the absence of CH and C=O bands, a weak amide II band near 1545 cm(-1), a shift of the amide I band to lower wave number, a decrease in the similar to 1450 cm(-1) peak to less than the similar to 1400 cm(-1) peak. Subtraction spectra indicate that the amide I and amide II bands of normal and malignant tissues have larger differences in peak positions and relative intensities. The statistical analysis results confirm this conclusion. The results indicate that FTIR fiber optic techniques provide important information about cancerous tissue of the stomach, which can be used to differentiate the malignant tissue from the normal tissue. Based on the above results we successfully realize the detection of the tumor tissues of digestive tract in vivo and in situ. And the results of detection cancer near operating room and in vivo and in situ in the operating room are consistent with the conclusions for the samples stored in liquid N-2, which is the basis for the clinical application.; Chemistry, Multidisciplinary; SCI(E); EI; 5; ARTICLE; 2; 167-175; 48
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/254135]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Xu, YZ,Yang, LM,Xu, Z,et al. Distinguishing malignant from normal stomach tissues and its in vivo, in situ measurement in operating process using FTIR Fiber-Optic techniques[J]. 中国科学b辑化学英文版,2005.
APA	Xu, YZ.,Yang, LM.,Xu, Z.,Zhao, Y.,Ling, XF.,...&Wu, JG.(2005).Distinguishing malignant from normal stomach tissues and its in vivo, in situ measurement in operating process using FTIR Fiber-Optic techniques.中国科学b辑化学英文版.
MLA	Xu, YZ,et al."Distinguishing malignant from normal stomach tissues and its in vivo, in situ measurement in operating process using FTIR Fiber-Optic techniques".中国科学b辑化学英文版 (2005).