Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two   non-planar alkaloids through interaction in lateral grooves

doi:10.1016/j.biochi.2009.03.007

CORC > 北京大学 > 化学与分子工程学院

	Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two non-planar alkaloids through interaction in lateral grooves
	Li, Qian ; Xiang, Junfeng ; Li, Xudong ; Chen, Lirong ; Xu, Xiaojie ; Tang, Yalin ; Zhou, Qiuju ; Li, Lin ; Zhang, Hong ; Sun, Hongxia ; Guan, Aijiao ; Yang, Qianfan ; Yang, Shu ; Xu, Guangzhi
刊名	biochimie
	2009
关键词	G-quadruplex Groove binding Non-planar Alkaloids ANTICANCER DRUG DESIGN HUMAN TELOMERIC REPEAT ANTITUMOR AGENTS RECOGNITION NMR D(TTAGGGT)(4) INHIBITOR TARGETS POTENT DERIVATIVES
DOI	10.1016/j.biochi.2009.03.007
英文摘要	Human DNA sequences consisting of tandem guanine (G) nucleotides can fold into a four-stranded structure named G-quadruplex via Hoogsteen hydrogen bonding. As the sequences forming G-quadruplex exist in essential regions of eukaryotic chromosomes and are involved in many important biological processes, the study of their biological functions has currently become a hotspot. Compounds selectively binding and stabilizing G-quadruplex structures have the potential to inhibit telomerase activity or alter oncogene expression levels and thus may act as antitumor agents. Most of reported G-quadruplex ligands generally have planar structures which stabilize G-quadruplex by pi-pi stacking. However, based on a pharmacophore-based virtual screening two non-planar G-quadruplex ligands were found. These two ligands exhibit good capability for G-quadruplex stabilization and prefer binding to paralleled G-quadruplex rather than to duplex DNA. The binding of these ligands to G-quadruplex may result from groove binding at a 2:1 stoichiometry. These results have shown that planar structures are not essential for G-quadruplex stabilizers, which may represent a new class of G-quadruplex-targeted agents as potential antitumor drugs. (C) 2009 Elsevier Masson SAS. All rights reserved.; Biochemistry & Molecular Biology; SCI(E); 34; ARTICLE; 7; 811-819; 91
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/247008]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Li, Qian,Xiang, Junfeng,Li, Xudong,et al. Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two non-planar alkaloids through interaction in lateral grooves[J]. biochimie,2009.
APA	Li, Qian.,Xiang, Junfeng.,Li, Xudong.,Chen, Lirong.,Xu, Xiaojie.,...&Xu, Guangzhi.(2009).Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two non-planar alkaloids through interaction in lateral grooves.biochimie.
MLA	Li, Qian,et al."Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two non-planar alkaloids through interaction in lateral grooves".biochimie (2009).