Discrimination of cyclic peptide diastereomers by electrospray   ionization tandem mass spectrometry

doi:10.1002/jms.1635

CORC > 北京大学 > 化学与分子工程学院

	Discrimination of cyclic peptide diastereomers by electrospray ionization tandem mass spectrometry
	Zheng, Bo ; Liu, Yiquan ; Li, Huihui ; Ye, Yunhua ; Gao, Xingming ; Yuan, Gu
刊名	journal of mass spectrometry
	2009
关键词	ESI mass spectrometry abundance ratio of ions cyclic peptide diastereomers epimer distinguishing diastereomer DIFFERENTIATION ISOMERS CYCLIZATION PAIRS
DOI	10.1002/jms.1635
英文摘要	In this research, the characteristic ions' abundance ratio between two isomers A and B in MS/MS mass spectra was defined as a parameter for discriminating diastereomers. Through this ratio, the discrimination of four pairs of cyclic peptide (CP) diastereomers was successfully achieved. Furthermore, in the analysis of diastereomers' mixtures, both calibration curve and calculational methods were substantiated to have high precision and accuracy. The average absolute errors of the two methods were 2.0 and 2.5% in the 48 measurements of 16 samples, respectively. This research provided a promising approach for the analysis of the CP diastereomers in the fields of asymmetrical synthesis, chiral natural products and structural biology by ESI-MS/MS. Copyright (C) 2009 John Wiley & Sons, Ltd.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000271722500008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biophysics; Chemistry, Organic; Spectroscopy; SCI(E); EI; 1; ARTICLE; 10; 1478-1481; 44
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/246215]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zheng, Bo,Liu, Yiquan,Li, Huihui,et al. Discrimination of cyclic peptide diastereomers by electrospray ionization tandem mass spectrometry[J]. journal of mass spectrometry,2009.
APA	Zheng, Bo,Liu, Yiquan,Li, Huihui,Ye, Yunhua,Gao, Xingming,&Yuan, Gu.(2009).Discrimination of cyclic peptide diastereomers by electrospray ionization tandem mass spectrometry.journal of mass spectrometry.
MLA	Zheng, Bo,et al."Discrimination of cyclic peptide diastereomers by electrospray ionization tandem mass spectrometry".journal of mass spectrometry (2009).