Tuning kinetics of controlled-release in disulfide-linked MSN-folate   conjugates with different fabrication procedures

doi:10.1016/j.matlet.2011.08.046

CORC > 北京大学 > 化学与分子工程学院

	Tuning kinetics of controlled-release in disulfide-linked MSN-folate conjugates with different fabrication procedures
	Guo, Rui ; Li, Le-Le ; Yang, Hua ; Zhang, Mei-Jin ; Fang, Chen-Jie ; Zhang, Tian-Lan ; Zhang, Yi-Bing ; Cui, Guo-Hui ; Peng, Shi-Qi ; Feng, Wei ; Yan, Chun-Hua
刊名	材料快报
	2012
关键词	Functional nanoparticles Porous materials Redox-responsive Controlled release First-order kinetics Zero-order kinetics MESOPOROUS MATERIALS SUSTAINED-RELEASE DRUG-DELIVERY SILICA ADSORPTION MCM-41 NANOPARTICLES MATRICES
DOI	10.1016/j.matlet.2011.08.046
英文摘要	A drug delivery system based on disulfide-linked MSN-folate conjugates is fabricated via co-condensation and post-grafting methods. The premature leakage before DDSs reach the specific site is eliminated due to the covalent conjugation, which is desirable for drug delivery, especially for the delivery of those highly toxic anticancer drugs. Interestingly, the controlled release responsive to redox stimuli is tunable by using different fabrication procedure. The system fabricated with co-condensation exhibits first-order release while that with post-grafting exhibits zero-order release. The constant release rate is an especially interesting behavior that avoids peaks in the rate of drug delivery. The cumulative release data were used to fit in Korsmeyer-Peppas model to figure out the release mechanism. The exponent n = 0.22 for MF1 indicates Fick diffusion while n = 0.49 for MF2 indicates non-Fick or anomalous diffusion. (C) 2011 Elsevier B.V. All rights reserved.; Materials Science, Multidisciplinary; Physics, Applied; SCI(E); EI; 5; ARTICLE; 1; 79-82; 66
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/236482]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Guo, Rui,Li, Le-Le,Yang, Hua,et al. Tuning kinetics of controlled-release in disulfide-linked MSN-folate conjugates with different fabrication procedures[J]. 材料快报,2012.
APA	Guo, Rui.,Li, Le-Le.,Yang, Hua.,Zhang, Mei-Jin.,Fang, Chen-Jie.,...&Yan, Chun-Hua.(2012).Tuning kinetics of controlled-release in disulfide-linked MSN-folate conjugates with different fabrication procedures.材料快报.
MLA	Guo, Rui,et al."Tuning kinetics of controlled-release in disulfide-linked MSN-folate conjugates with different fabrication procedures".材料快报 (2012).