Single-wall carbon nanohorns (SWNHs) inhibited proliferation of human   glioma cells and promoted its apoptosis

doi:10.1007/s11051-013-1861-5

CORC > 北京大学 > 化学与分子工程学院

	Single-wall carbon nanohorns (SWNHs) inhibited proliferation of human glioma cells and promoted its apoptosis
	Li, Yunjun ; Zhang, Jinqian ; Zhao, Ming ; Shi, Zujin ; Chen, Xin ; He, Xihui ; Han, Nanyin ; Xu, Ruxiang
刊名	journal of nanoparticle research
	2013
关键词	Single-walled carbon nanohorns (SWNHs) Proliferation Apoptosis Glioma MACROPHAGE CELLS DRUG CARRIERS IN-VITRO NANOPARTICLES NANOTUBES TOXICITY ENHANCEMENT CONJUGATE CYTOPLASM CISPLATIN
DOI	10.1007/s11051-013-1861-5
英文摘要	Although single-wall carbon nanohorns (SWNHs) have been demonstrated to accumulate to cytotoxic levels within organs of various animal models and cell types, they have been exploited for cancer therapies. The role of SWNHs in human glioma cell lines was unclear. To address this question, the research about direct role of SWNHs on the growth, proliferation, and apoptosis of human glioma cell lines (U87, U251, and U373) had been performed. Our results indicate that particle size of SWNHs in water is between 342 and 712 nm, the films of SEM show that SWNHs on PS surface are individual particles. SWNHs significantly delayed mitotic entry of human glioma cell lines cells, and inhibited its proliferation in a time-and dose-dependent manner. SWNHs induced a significant increase in G1 phase and inhibition of S phase followed the gradually increasing concentrations. SWNHs in human glioma cell lines cells significantly induced apoptosis followed by their gradually increasing concentrations. The TEM images showed that individual spherical SWNHs particles smaller than 100 nm in diameters were localized inside lysosomes of human glioma cell lines. SWNHs inhibited mitotic entry, growth, and proliferation of human glioma cell lines, and promoted its apoptosis. SWNHs may be a novel opportunity or method for the research on treatment of human glioma.; Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; SCI(E); EI; 0; ARTICLE; 8; 15
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/221567]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Li, Yunjun,Zhang, Jinqian,Zhao, Ming,et al. Single-wall carbon nanohorns (SWNHs) inhibited proliferation of human glioma cells and promoted its apoptosis[J]. journal of nanoparticle research,2013.
APA	Li, Yunjun.,Zhang, Jinqian.,Zhao, Ming.,Shi, Zujin.,Chen, Xin.,...&Xu, Ruxiang.(2013).Single-wall carbon nanohorns (SWNHs) inhibited proliferation of human glioma cells and promoted its apoptosis.journal of nanoparticle research.
MLA	Li, Yunjun,et al."Single-wall carbon nanohorns (SWNHs) inhibited proliferation of human glioma cells and promoted its apoptosis".journal of nanoparticle research (2013).