Fibril Aggregates Formed by a Glatiramer-Mimicking Random Copolymer of   Amino Acids

doi:10.1021/la501622t

CORC > 北京大学 > 化学与分子工程学院

	Fibril Aggregates Formed by a Glatiramer-Mimicking Random Copolymer of Amino Acids
	Lai, Jingjing ; Fu, Wenxin ; Zhu, Lin ; Guo, Ruohai ; Liang, Dehai ; Li, Zhibo ; Huang, Yanbin
刊名	langmuir
	2014
关键词	SECONDARY STRUCTURE ANALYSES X-RAY-DIFFRACTION AMYLOID FIBRILS DISEASE POLYPEPTIDES MECHANISM TAU
DOI	10.1021/la501622t
英文摘要	Amyloid formation is now considered a universal and intrinsic property of all proteins, irrespective of their sequences. Therefore, it is interesting to see whether random copolymers of amino acids can also form amyloid aggregates. Here we use a copolymer of 4 amino acids, mimicking the clinically used drug Glatiramer, and demonstrate that it does form amyloid-like fibrils in the aqueous solution despite its random sequence structure. The fibrillar aggregates show an alanine-rich beta-sheet secondary structure, proving the high tolerance of amyloid aggregates to the sequence irregularity in poly(amino acid)s, and suggesting the potential application of random copolymers as amyloid materials.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000338089600024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary; SCI(E); EI; 6; ARTICLE; dliang@pku.edu.cn; zbli@iccas.ac.cn; yanbin@tsinghua.edu.cn; 24; 7221-7226; 30
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/211787]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Lai, Jingjing,Fu, Wenxin,Zhu, Lin,et al. Fibril Aggregates Formed by a Glatiramer-Mimicking Random Copolymer of Amino Acids[J]. langmuir,2014.
APA	Lai, Jingjing.,Fu, Wenxin.,Zhu, Lin.,Guo, Ruohai.,Liang, Dehai.,...&Huang, Yanbin.(2014).Fibril Aggregates Formed by a Glatiramer-Mimicking Random Copolymer of Amino Acids.langmuir.
MLA	Lai, Jingjing,et al."Fibril Aggregates Formed by a Glatiramer-Mimicking Random Copolymer of Amino Acids".langmuir (2014).