Investigation of the Enantioselectivity of Tetramethylammonium   L-hydroxyproline Ionic Liquid as a Novel Chiral Ligand in   Ligand-Exchange CE and Ligand-Exchange MEKC

doi:10.1002/chir.22388

CORC > 北京大学 > 化学与分子工程学院

	Investigation of the Enantioselectivity of Tetramethylammonium L-hydroxyproline Ionic Liquid as a Novel Chiral Ligand in Ligand-Exchange CE and Ligand-Exchange MEKC
	Liu, Ruijuan ; Du, Yingxiang ; Chen, Jiaquan ; Zhang, Qi ; Du, Shuaijing ; Feng, Zijie
刊名	chirality
	2015
关键词	chiral ligand enantioseparation ligand-exchange capillary electrophoresis tetramethylammonium L-hydroxyproline ionic liquids MICELLAR ELECTROKINETIC CHROMATOGRAPHY AMINO-ACID ENANTIOMERS CAPILLARY-ELECTROPHORESIS ENANTIOSEPARATION SYSTEMS SYNERGISTIC SYSTEM BASIC DRUGS SEPARATION SELECTOR ADDITIVES GLYCOGEN
DOI	10.1002/chir.22388
英文摘要	Chiral ionic liquids (ILs) have drawn more and more attention in separation science; however, only a few papers focused on the application of chiral ILs as chiral ligands in LE-CE. In this article, a novel amino acid ionic liquid (AAIL), tetramethylammonium L-hydroxyproline ([TMA][L-OH-Pro]), was first applied as a chiral ligand to evaluate its enantioselectivity towards several aromatic amino acids in ligand-exchange capillary electrophoresis (LE-CE) and ligand-exchange micellar electrokinetic capillary chromatography (LE-MEKC). In the LE-CE system, excellent separations were achieved for tryptophan (Rs=3.03) and 3, 4-dihydroxyphenylalanine (DOPA) (Rs=4.35). Several parameters affecting the enantioseparation were systematically investigated, including AAIL concentration, type and concentration of central metal ion, buffer pH, as well as applied voltage. The optimum separation was obtained with 60mM AAIL containing 30mM Cu (II) at pH4.5. Additionally, an LE-MEKC system was established to further study the enantioselectivity of [TMA][L-OH-Pro] towards selected analytes. As observed, the separations of the enantiomers of tryptophan, phenylalanine, and histidine were all improved compared to the LE-CE system. The results indicated that the application of AAILs as chiral ligands is a promising method in chiral separation science. Chirality 27:58-63, 2015. (c) 2014 Wiley Periodicals, Inc.; Chemistry, Medicinal; Chemistry, Analytical; Chemistry, Organic; Pharmacology & Pharmacy; SCI(E); 2; ARTICLE; du_yingxiang@126.com; 1; 58-63; 27
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/206702]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Liu, Ruijuan,Du, Yingxiang,Chen, Jiaquan,et al. Investigation of the Enantioselectivity of Tetramethylammonium L-hydroxyproline Ionic Liquid as a Novel Chiral Ligand in Ligand-Exchange CE and Ligand-Exchange MEKC[J]. chirality,2015.
APA	Liu, Ruijuan,Du, Yingxiang,Chen, Jiaquan,Zhang, Qi,Du, Shuaijing,&Feng, Zijie.(2015).Investigation of the Enantioselectivity of Tetramethylammonium L-hydroxyproline Ionic Liquid as a Novel Chiral Ligand in Ligand-Exchange CE and Ligand-Exchange MEKC.chirality.
MLA	Liu, Ruijuan,et al."Investigation of the Enantioselectivity of Tetramethylammonium L-hydroxyproline Ionic Liquid as a Novel Chiral Ligand in Ligand-Exchange CE and Ligand-Exchange MEKC".chirality (2015).