QQ客服 官方微博 反馈留言

	Inhibition of nitrobenzene-induced DNA and hemoglobin adductions by dietary constituents
	Li Hongli ; Cheng Yan ; Wang Haifang ; Sun Hongfang ; Liu Yuanfang ; Liu Kexin ; Peng Shixiang
	2003
英文摘要	Nitrobenzene (NB), a widely used industrial chemical, is a likely human carcinogen. Many dietary constituents can suppress the DNA-adduction, acting as the inhibitors of cancer. In this study, we investigated the inhibitory effects of vitamin C (VC), vitamin E (VE), tea polyphenols (TP), garlic squeeze, curcumin, and grapestone extract on NB-DNA and NB-hemoglobin (Hb) adductions in mice using an ultrasensitive method of accelerator mass spectrometry (AMS) with 14C-labelled nitrobenzene. All of these dietary constituents showed their inhibitory effects on DNA or Hb adduction. VC, VE, TP and grapestone extract could efficaciously inhibit the adductions by 33-50%, and all of these six agents could inhibit Hb adduction by 30-64%. We also investigated resveratrol, curcumin, VC and VE as inhibitors of NB-DNA adduction in vitro using liquid scintillation counting technique. These agents in the presence of NADPH and S9 components also pronouncedly blocked DNA adduction in a dose-dependent profile. Our study suggests that these seven constituents may interrupt the process of NB-induced chemical carcinogenesis.; SCI(E); EI; PubMed; 0; 3; 291-8; 58
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/200154]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Li Hongli,Cheng Yan,Wang Haifang,et al. Inhibition of nitrobenzene-induced DNA and hemoglobin adductions by dietary constituents[J],2003.
APA	Li Hongli.,Cheng Yan.,Wang Haifang.,Sun Hongfang.,Liu Yuanfang.,...&Peng Shixiang.(2003).Inhibition of nitrobenzene-induced DNA and hemoglobin adductions by dietary constituents..
MLA	Li Hongli,et al."Inhibition of nitrobenzene-induced DNA and hemoglobin adductions by dietary constituents".(2003).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。