Superoxide flashes: Elemental events of mitochondrial ROS signaling in   the heart

doi:10.1016/j.yjmcc.2012.02.007

CORC > 北京大学 > 化学与分子工程学院

	Superoxide flashes: Elemental events of mitochondrial ROS signaling in the heart
	Wang, Xianhua ; Jian, Chongshu ; Zhang, Xing ; Huang, Zhanglong ; Xu, Jiejia ; Hou, Tingting ; Shang, Wei ; Ding, Yi ; Zhang, Wanrui ; Ouyang, Meng ; Wang, Yuefan ; Yang, Zhen ; Zheng, Ming ; Cheng, Heping
刊名	journal of molecular and cellular cardiology
	2012
关键词	Superoxide flash Mitochondria Reactive oxygen species (ROS) Mitochondrial permeability transition pore Local ROS signaling PERMEABILITY TRANSITION PORE DEPENDENT ANION CHANNELS CELL-DEATH CYCLOPHILIN-D CARDIAC MYOCYTES OXIDATIVE-STRESS ISOLATED HEPATOCYTES MOLECULAR-MECHANISM REPERFUSION INJURY HYDROGEN-PEROXIDE
DOI	10.1016/j.yjmcc.2012.02.007
英文摘要	The role of mitochondrial reactive oxygen species (mitoROS) in cellular function remains obscure. By synthesizing recent data, we propose here that local dynamic mitoROS in the form of "superoxide flashes" serve as "signaling ROS" rather than "homeostatic ROS", distinguishable from basal mitoROS due to constitutive leakage of the electron transfer chain (ETC). Individual superoxide flashes are 10-s mitoROS bursts that are compartmentalized to a single mitochondrion or local mitochondrial networks. As a highly-conserved universal mitochondrial activity, it occurs in intact cells, in ex vivo beating hearts, and even in living animals. Unlike basal mitoROS, superoxide flashes are ignited by transient openings of a type of mitochondrial permeability transition pore (mPTP). and their incidence is richly regulated by an array of factors that converge on either the mPTP or ETC. Emerging evidence has shown that superoxide flashes decode dietary and metabolic status or exercise, gauge oxidative stress (e.g., during reoxygenation after hypoxia or anoxia), and constitute early mitochondrial signals that initiate oxidative stress-related apoptosis in a context-dependent manner. That they make only a miniscule contribution to global ROS attests to the high efficiency of local ROS signaling. However, the exact mechanisms underlying superoxide flash formation, regulation and function remain uncertain. Future investigation is warranted to uncover the cellular logic and molecular pathways of local dynamic mitoROS signaling in heart muscle cells and many other cell types. (C) 2012 Elsevier Ltd. All rights reserved.; Cardiac & Cardiovascular Systems; Cell Biology; SCI(E); PubMed; 21; REVIEW; 5; 940-948; 52
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/192503]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Wang, Xianhua,Jian, Chongshu,Zhang, Xing,et al. Superoxide flashes: Elemental events of mitochondrial ROS signaling in the heart[J]. journal of molecular and cellular cardiology,2012.
APA	Wang, Xianhua.,Jian, Chongshu.,Zhang, Xing.,Huang, Zhanglong.,Xu, Jiejia.,...&Cheng, Heping.(2012).Superoxide flashes: Elemental events of mitochondrial ROS signaling in the heart.journal of molecular and cellular cardiology.
MLA	Wang, Xianhua,et al."Superoxide flashes: Elemental events of mitochondrial ROS signaling in the heart".journal of molecular and cellular cardiology (2012).