Bacterial chemoreceptors and chemoeffectors

doi:10.1007/s00018-014-1770-5

CORC > 北京大学 > 化学与分子工程学院

	Bacterial chemoreceptors and chemoeffectors
	Bi, Shuangyu ; Lai, Luhua
刊名	cellular and molecular life sciences
	2015
关键词	Chemotactic response Receptor Ligand Molecular mechanism Receptor design COLI SERINE CHEMORECEPTOR LIGAND-BINDING DOMAIN DISULFIDE CROSS-LINKING ESCHERICHIA-COLI ASPARTATE RECEPTOR HAMP DOMAIN SIGNAL-TRANSDUCTION CHEMOTAXIS RECEPTOR MUTATIONAL ANALYSIS SENSORY ADAPTATION
DOI	10.1007/s00018-014-1770-5
英文摘要	Bacteria use chemotaxis signaling pathways to sense environmental changes. Escherichia coli chemotaxis system represents an ideal model that illustrates fundamental principles of biological signaling processes. Chemoreceptors are crucial signaling proteins that mediate taxis toward a wide range of chemoeffectors. Recently, in deep study of the biochemical and structural features of chemoreceptors, the organization of higher-order clusters in native cells, and the signal transduction mechanisms related to the on-off signal output provides us with general insights to understand how chemotaxis performs high sensitivity, precise adaptation, signal amplification, and wide dynamic range. Along with the increasing knowledge, bacterial chemoreceptors can be engineered to sense novel chemoeffectors, which has extensive applications in therapeutics and industry. Here we mainly review recent advances in the E. coli chemotaxis system involving structure and organization of chemoreceptors, discovery, design, and characterization of chemoeffectors, and signal recognition and transduction mechanisms. Possible strategies for changing the specificity of bacterial chemoreceptors to sense novel chemoeffectors are also discussed.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000348918500004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemistry & Molecular Biology; Cell Biology; SCI(E); PubMed; 6; REVIEW; lhlai@pku.edu.cn; 4; 691-708; 72
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/188558]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Bi, Shuangyu,Lai, Luhua. Bacterial chemoreceptors and chemoeffectors[J]. cellular and molecular life sciences,2015.
APA	Bi, Shuangyu,&Lai, Luhua.(2015).Bacterial chemoreceptors and chemoeffectors.cellular and molecular life sciences.
MLA	Bi, Shuangyu,et al."Bacterial chemoreceptors and chemoeffectors".cellular and molecular life sciences (2015).