Radiation synthesis of gelatin/CM-chitosan/beta-tricalcium phosphate   composite scaffold for bone tissue engineering

doi:10.1016/j.msec.2012.02.029

CORC > 北京大学 > 化学与分子工程学院

	Radiation synthesis of gelatin/CM-chitosan/beta-tricalcium phosphate composite scaffold for bone tissue engineering
	Zhou, Ying ; Xu, Ling ; Zhang, Xiangmei ; Zhao, Yinghui ; Wei, Shicheng ; Zhai, Maolin
刊名	materials science engineering c materials for biological applications
	2012
关键词	Gelatin Carboxymethyl chitosan beta-tricalcium phosphate Ultrasonic treatment Radiation crosslinking Bone tissue engineering HYDROXYAPATITE FILMS BIOCOMPATIBILITY CHITIN SIZE
DOI	10.1016/j.msec.2012.02.029
英文摘要	A series of biodegradable composite scaffolds was fabricated from an aqueous solution of gelatin, carboxymethyl chitosan (CM-chitosan) and beta-tricalcium phosphate (beta-TCP) by radiation-induced crosslinking at ambient temperature. Ultrasonic treatment on the polymer solutions significantly influenced the distribution of (beta-TCP particles. An ultrasonic time of 20 min, followed by 30 kGy irradiation induced a crosslinked scaffold with homogeneous distribution of beta-TCP particles, interconnected porous structure, sound swelling capacity and mechanical strength. Fourier Transform Infrared Spectroscopy and X-ray Diffraction analysis indicated that beta-TCP successfully incorporated with the network of gelatin and CM-chitosan. In vivo implantation of the scaffold into the mandible of beagle dog revealed that the scaffolds had excellent biocompatibility and the presence of beta-TCP can accelerate bone regeneration. The comprehensive results of this study paved way for the application of gelatin/CM-chitosan/beta-TCP composite scaffolds as candidate of bone tissue engineering material. (C) 2012 Elsevier By. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000303299300054&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Materials Science, Biomaterials; SCI(E); EI; 11; ARTICLE; 4; 994-1000; 32
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/154657]
专题	化学与分子工程学院工学院
推荐引用方式 GB/T 7714	Zhou, Ying,Xu, Ling,Zhang, Xiangmei,et al. Radiation synthesis of gelatin/CM-chitosan/beta-tricalcium phosphate composite scaffold for bone tissue engineering[J]. materials science engineering c materials for biological applications,2012.
APA	Zhou, Ying,Xu, Ling,Zhang, Xiangmei,Zhao, Yinghui,Wei, Shicheng,&Zhai, Maolin.(2012).Radiation synthesis of gelatin/CM-chitosan/beta-tricalcium phosphate composite scaffold for bone tissue engineering.materials science engineering c materials for biological applications.
MLA	Zhou, Ying,et al."Radiation synthesis of gelatin/CM-chitosan/beta-tricalcium phosphate composite scaffold for bone tissue engineering".materials science engineering c materials for biological applications (2012).