Synthesis of linear functionalized polyesters by controlled atom   transfer radical polyaddition reactions

doi:10.1039/c2py20319g

CORC > 北京大学 > 化学与分子工程学院

	Synthesis of linear functionalized polyesters by controlled atom transfer radical polyaddition reactions
	Dong, Bo-Tao ; Li, Zi-Long ; Zhang, Li-Jing ; Du, Fu-Sheng ; Li, Zi-Chen
刊名	polymer chemistry
	2012
关键词	RING-OPENING POLYMERIZATION ACTIVATION RATE CONSTANTS ALIPHATIC POLYESTERS DEGRADABLE POLYMERS CLICK CHEMISTRY BIODEGRADABLE POLYMERS DRUG-DELIVERY EQUILIBRIUM-CONSTANTS DICARBOXYLIC-ACID GENE DELIVERY
DOI	10.1039/c2py20319g
英文摘要	We report on the facile synthesis of a range of new linear functionalized polyesters by controlled atom transfer radical polyaddition reactions. One bis-styrenic type monomer, 1,2-bis(4-vinylbenzyloxy) ethane (AA), and two bis-methacrylate type ATRP initiators, 1,2-bis(2-bromoisobutyryloxy) ethane (BB) and bis[2-(2-bromoisobutyryloxy) ethyl] disulfide (BssB), were synthesized. The polymerizations of monomer AA with BB and BssB were carried out in anisole at 0 degrees C, using Cu/CuBr2 coupled with N,N-bis(2-pyridylmethyl)octylamine (BPMOA) as the catalyst. The polymerization kinetics were investigated and the polymers were characterized by GPC and NMR, both confirming the step-wise mechanism with the formation of the expected linear polyesters having pendent bromides. When BssB was used, additional disulfide groups were incorporated in the polyester main chain, imparting a tunable degradation mechanism to the polyester. Moreover, the pendent bromides on the polymers could serve as initiation sites or precursors to azides to prepare biodegradable graft copolymers. This has been proven by two examples, reactivating the pendent bromides at room temperature to initiate the ATRP of other methacrylates, and transforming these groups into azido-groups by substitution reaction followed by click chemistry with alkynyl-terminated polyethylene glycol.; Polymer Science; SCI(E); EI; 5; ARTICLE; 9; 2523-2530; 3
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/150974]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Dong, Bo-Tao,Li, Zi-Long,Zhang, Li-Jing,et al. Synthesis of linear functionalized polyesters by controlled atom transfer radical polyaddition reactions[J]. polymer chemistry,2012.
APA	Dong, Bo-Tao,Li, Zi-Long,Zhang, Li-Jing,Du, Fu-Sheng,&Li, Zi-Chen.(2012).Synthesis of linear functionalized polyesters by controlled atom transfer radical polyaddition reactions.polymer chemistry.
MLA	Dong, Bo-Tao,et al."Synthesis of linear functionalized polyesters by controlled atom transfer radical polyaddition reactions".polymer chemistry (2012).