Simultaneous separation and sensitive detection of four beta 2-agonists   in biological specimens by CE-UV using a field-enhanced sample injection   method

doi:10.1039/c4ay02385d

CORC > 北京大学 > 化学与分子工程学院

	Simultaneous separation and sensitive detection of four beta 2-agonists in biological specimens by CE-UV using a field-enhanced sample injection method
	Chen, Cheng ; Meng, Lingchen ; Li, Meixian ; Zhu, Zhiwei
刊名	analytical methods
	2015
关键词	CAPILLARY-ELECTROPHORESIS HUMAN URINE MASS-SPECTROMETRY DOPING CONTROL CLENBUTEROL SALBUTAMOL FENOTEROL BETA(2)-AGONISTS RACTOPAMINE STACKING
DOI	10.1039/c4ay02385d
英文摘要	A rapid, sensitive and cost-effective CE-UV method has been developed for the simultaneous separation and sensitive determination of clenbuterol, salbutamol, ractopamine and fenoterol in pig blood and human urine samples. Field-enhanced sample injection (FESI) as an effective online concentration technique was applied to improve the detection sensitivity of beta 2-agonists. Several factors, such as the concentration and pH of the background solution, sample matrix, injection time and voltage, and the length of the water plug, were systematically optimized. Under the optimum conditions, the detection limits of the beta 2-agonists range from 2.7 to 7.2 nM, which were improved nearly 2000 times by CE-UV compared with conventional methods, except for fenoterol. Eventually, the proposed method was successfully applied to the analysis of spiked blood and urine samples with good recoveries, which provides a novel method to monitor the illegal use of b2-agonists in athletes and livestock.; Chemistry, Analytical; Food Science & Technology; Spectroscopy; SCI(E); EI; 0; ARTICLE; zwzhu@pku.edu.cn; 1; 175-180; 7
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/150351]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Chen, Cheng,Meng, Lingchen,Li, Meixian,et al. Simultaneous separation and sensitive detection of four beta 2-agonists in biological specimens by CE-UV using a field-enhanced sample injection method[J]. analytical methods,2015.
APA	Chen, Cheng,Meng, Lingchen,Li, Meixian,&Zhu, Zhiwei.(2015).Simultaneous separation and sensitive detection of four beta 2-agonists in biological specimens by CE-UV using a field-enhanced sample injection method.analytical methods.
MLA	Chen, Cheng,et al."Simultaneous separation and sensitive detection of four beta 2-agonists in biological specimens by CE-UV using a field-enhanced sample injection method".analytical methods (2015).