H-1, C-13 and N-15 resonance assignments of SARS-CoV main protease N-terminal domain | |
Zhang, Shengnan ; Zhong, Nan ; Ren, Xiaobai ; Jin, Changwen ; Xia, Bin | |
刊名 | biomolecular nmr assignments
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2011 | |
关键词 | SARS-CoV Main protease N-terminal domain NMR ACUTE RESPIRATORY SYNDROME SYNDROME CORONAVIRUS PROTEINASE DIMER FORM |
DOI | 10.1007/s12104-010-9287-9 |
英文摘要 | The main protease (M-pro) of severe acute respiratory syndrome coronavirus (SARS-CoV) plays an essential role in the extensive proteolytic processing of the viral polyproteins (pp1a and pp1ab), and it is an important target for anti-SARS drug development. SARS-CoV M-pro is composed of a catalytic N-terminal domain and an alpha-helical C-terminal domain linked by a long loop. Even though the N-terminal domain of SARS-CoV M-pro adopts a similar chymotrypsin-like fold as that of piconavirus 3C protease, the extra C-terminal domain is required for SARS-CoV M-pro to be enzymatically active. Here, we reported the NMR assignments of the SARS-CoV M-pro N-terminal domain alone, which are essential for its solution structure determination.; Biophysics; Spectroscopy; SCI(E); PubMed; 0; ARTICLE; 2; 143-145; 5 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/150013] ![]() |
专题 | 化学与分子工程学院 生命科学学院 |
推荐引用方式 GB/T 7714 | Zhang, Shengnan,Zhong, Nan,Ren, Xiaobai,et al. H-1, C-13 and N-15 resonance assignments of SARS-CoV main protease N-terminal domain[J]. biomolecular nmr assignments,2011. |
APA | Zhang, Shengnan,Zhong, Nan,Ren, Xiaobai,Jin, Changwen,&Xia, Bin.(2011).H-1, C-13 and N-15 resonance assignments of SARS-CoV main protease N-terminal domain.biomolecular nmr assignments. |
MLA | Zhang, Shengnan,et al."H-1, C-13 and N-15 resonance assignments of SARS-CoV main protease N-terminal domain".biomolecular nmr assignments (2011). |
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