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	交联聚磷酸酯的合成及其释药性能研究; Synthesis of crosslinked polyphosphates and drug release
	罗毅 ; 卓仁禧 ; 范昌烈
	1995
关键词	交联聚磷酸酯 5－氟尿嘧啶 控制释放 crosslinked polyphosphate 5-fluorouracil drug release
英文摘要	以（ｉ－Ｂｕ）_３Ａｌ为引发剂研究了２－氢－氧－１，３，２－二氧五环磷酸酯，２－氢－２－氧－１，３，２－二氧六环磷酸酯的开环均聚和共聚合反应，然后经过氯化、水解获得了交联聚磷酸酯材料。以合成的交联聚磷酸酯为药物载体，采用单层骨架片、双层骨架片和夹心片的载药方式，对抗肿瘤药物５－氟尿嘧啶进行了控制释放，获得了较好的释药效果。; Ring-opening polymerizations of 2-hydro-2-oxo-1,3, 2-dioxa-phospholan and/or 2-hydro-2-oxo-1,3, 2-dioxaphosphorinane were studied using (i-Bu(3))Al as initiator. After chlorination and hydrolysis, crosslinked polymers were obtained, The in vitro release of 5-fluorouracil from its single-matrix pellets, double-layered pellets and sandwich pellet with the crosslinked polyphosphates as drug carriers were carried out in phosphate buffer solution (pH 7. 4) at 37 degrees C. Sustained release from the sandwich pellet was more controlled than that from the single-matrix pellets and double-layered pellets.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995TP29500039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; SCI(E); 中文核心期刊要目总览(PKU); 中国科学引文数据库(CSCD); 5; 10; 1633-1636; 16
语种	中文
出处	SCI ; 知网
出版者	高等学校化学学报
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/81142]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	罗毅,卓仁禧,范昌烈. 交联聚磷酸酯的合成及其释药性能研究, Synthesis of crosslinked polyphosphates and drug release. 1995-01-01.

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