蛋白质相互作用预测、设计与调控; Protein-Protein Interaction: Prediction, Design, and Modulation | |
张长胜 ; 来鲁华 | |
2012 | |
关键词 | 蛋白质相互作用 相互作用预测 蛋白质-蛋白质对接 蛋白质相互作用设计 蛋白质药物 药物设计 Protein-protein interaction Interaction prediction Protein-protein docking Protein-protein interaction design Protein drug Drug design |
英文摘要 | 蛋白质相互作用是生命活动在分子水平上的基本事件.蛋白质相互作用的三维图像可以给出关键生命活动过程的分子细节.了解蛋白质相互作用的原理有助于揭示生命活动的机制,并在此基础上开展有重要价值的蛋白质设计.本文对于蛋白质相互作用预测、设计和调控研究的近期进展进行了总结归纳,介绍了作者实验室在相关领域的研究进展,并对今后的研究方向进行了展望.主要包括:(1)蛋白质相互作用网络、蛋白质相互作用机制和蛋白质复合物结构计算分析;(2)基于序列、结合位点以及复合物结构的蛋白质相互作用预测;(3)蛋白质相互作用设计方法;(4)利用化学分子调控蛋白质相互作用的方法;(5)针对蛋白质相互作用的蛋白质药物设计方法.; Protein-protein interactions are the essential events in life at the molecular level. The three-dimensional structures of protein-protein interactions provide clear pictures for the molecular details of various cellular processes. Understanding the basics of protein-protein interaction provides clues for revealing the secret of life, and useful information for designing proteins for various application purposes. The present review summarizes recent progresses of protein-protein interaction prediction, design, and modulation study, briefly introduces the progresses in the authors' group, and discusses future directions of the field. Protein-protein interaction network analysis, protein-protein interaction principles, and computational analysis of interfaces are briefly reviewed first. Methods and progress for predicting protein-protein interaction at sequence level, interaction-site level, and complex-structure level are given. Based on the knowledge about the nature of protein-protein interactions, protein-protein interaction design and modulation can be done on purpose. We give a summary of three kinds of protein-protein interaction design methods: redesign, grafting, and de novo, and three kinds of protein-protein interaction modulation methods using small molecules: direct competition, allosteric modulation, and stabilization. Protein design approaches for potential therapeutic applications targeting protein-protein interactions are also discussed.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000310181300018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; SCI(E); 中文核心期刊要目总览(PKU); 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 3; 10; 2363-2380; 28 |
语种 | 中文 |
出处 | 万方 ; 知网 ; SCI |
出版者 | 物理化学学报 |
内容类型 | 其他 |
源URL | [http://hdl.handle.net/20.500.11897/79731] |
专题 | 化学与分子工程学院 生命科学学院 |
推荐引用方式 GB/T 7714 | 张长胜,来鲁华. 蛋白质相互作用预测、设计与调控, Protein-Protein Interaction: Prediction, Design, and Modulation. 2012-01-01. |
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