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	金属硫蛋白与 Cd~(2+)、Pb~(2+)络合反应的微量量热滴定; Microcalorimetry study on the reaction of metallothionein with Cd2+ and Pb2+
	郇宇 ; 褚德萤 ; 汤勇 ; 曹炜
	2000
关键词	金属硫蛋白 镉离子 铅离子 等温微量滴定量热 metallothionein cadmium( II) ion lead ( II) ion isothermal titration calorimetry
英文摘要	Metallothionein, a class of low molecular weight, metal- and cysteine-rich Proteins, are postulated to play a central role in metal-related biological processes such as the detoxification of Cd~(2+)and Pb~(2+). The thermal Properties of the interactions of rabbit liver Zn_7MT2 and apo-MT2 with Cd~(...; Metallothionein, a class of low molecular weight, metal- and cysteine-rich proteins, are postulated to play a central role in metal-related biological processes such as the detoxification of Cd2+ and Pb2+. The thermal properties of the interactions of rabbit liver Zn(7)MT2 and apo-MT2 with Cd2+ and Pb2+ were studied using isothermal titration calorimeter. The same product Cd7MT formed in the reactions of Cd2+ with Zn(7)MT2 and apo-MT2, while the reactions of Pb2+ with Zn(7)MT2 and apo-MT2 produced two MT species Pb7MT and Pb7MT'. The thermodynamic parameters (Delta H, Delta G, Delta S, etc.) for the reactions of MT with 1 mol metal ions were measured at 293.15 K, pH 4.70. All of these reactions are spontaneous, exothermic processes. The values of Delta G and K show that Cd2+ is more affinitive to MT than Pb2+. The equilibrium constants K of the replacement reactions of Zn(7)MT2 by 1 mol Cd2+ and Pb2+ are 2.7 x 10(5) and 1.3 x 10(5) respectively, that means the concentrations of free Cd2+ and Pb2+ are depressed to about 1.0 x 10(-5) after the reactions with Zn(7)MT2. These data can be used to evaluate quantitatively the ability of MT in Cd2+ and Pb2+ detoxificatio.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000088885300018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; SCI(E); 中文核心期刊要目总览(PKU); 中国科学引文数据库(CSCD); 5; 08; 764-768; 16
语种	中文
出处	万方 ; 知网 ; SCI
出版者	物理化学学报
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/78479]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	郇宇,褚德萤,汤勇,等. 金属硫蛋白与 Cd~(2+)、Pb~(2+)络合反应的微量量热滴定, Microcalorimetry study on the reaction of metallothionein with Cd2+ and Pb2+. 2000-01-01.

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