| 光活性酮咯酸衍生物的拆分及绝对构型的测定; The resolution of the optical active derivatives of ketorolac and the determination of its absolute configuration | |
| 宁家成 ; 杨鳌 ; 关烨第 ; 王哲明 ; 严纯华 | |
| 2002 | |
| 关键词 | 酮咯酸 酰胺 非对映异构体 拆分 晶体结构 绝对构型 ketorolac amide diastereoisomer resolution crystal structure absolute configuration |
| 英文摘要 | 酮咯酸与L-脯氨酸苄酯在缩合剂作用下形成酰胺,用柱层析分离了一对非对映异构体并进行了表征.用单晶X衍射测定了酮咯酸脯氨酸苄酯酰胺一个异构体的晶体结构,并用内参法确定了其绝对构型.晶体属正交晶系,空间群P212121,晶胞参数a=0.89645(1)nm,b=1.27123(2)nm,c=2.07621(4)nm,V=2.36604(6)nm3,Z=4,最终偏离因子R1=0.0464.; A pair of diastereoisomer of Pro-Obzl of keterolac amide, formed by the reaction of(+/-)-ketorolac and L-proline under the action of condensation agent, were resolved using column chromatography and characterized by H-1 NMR, C-13 NMR, IR, MS spectra and elemental analysis. The crystal structure of one diastereoisomer of the an-tides was determined by single crystal diffraction analysis, and the absolute configuration of which was deduced by internal reference. The crystal belongs to orthorhombic space group P212121. Crystallographic data are: a = 0. 896 45(1) nm, b = 1. 271 23(2) nm, c = 2.076 21(4) nm, V= 2.366 04(6) nm(3), Z = 4, R-1 = 0. 0464.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000178107400011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; SCI(E); 中文核心期刊要目总览(PKU); 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 0; 09; 821-824; 18 |
| 语种 | 中文 |
| 出处 | 万方 ; 知网 ; SCI |
| 出版者 | 物理化学学报 |
| 内容类型 | 其他 |
| 源URL | [http://hdl.handle.net/20.500.11897/78267]  |
| 专题 | 化学与分子工程学院 |
| 推荐引用方式 GB/T 7714 | 宁家成,杨鳌,关烨第,等. 光活性酮咯酸衍生物的拆分及绝对构型的测定, The resolution of the optical active derivatives of ketorolac and the determination of its absolute configuration. 2002-01-01. |
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