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	直肠癌及直肠正常组织的IR和~1H及~(31)P NMR谱研究; Study on malignant and normal rectum tissues using IR and 1H and 31P NMR spectroscopy
	高秀香 ; 姚宏伟 ; 杜俊凯 ; 赵梅仙 ; 齐剑 ; 李慧珍 ; 潘庆华 ; 徐怡庄 ; 吴瑾光
	2009
关键词	魔角旋转 核磁共振 直肠癌 早期诊断 Magic angle spinning Nuclear magnetic resonance Rectum cancer Early diagnosis
英文摘要	对12例直肠组织的红外光谱图进行了测定,并对6例直肠癌变及正常组织的固体1H和31PNMR谱与另外6例直肠癌变及正常组织的液体1H和31P-NMR谱进行研究。结果表明,(1)直肠癌变和正常组织的红外光谱中存在明显差异。(2)在固体1H和31P NMR谱中,1H NMR谱上癌组织的脂肪酸与水相关的特征峰面积的比值I(5+6+7)/I(1+2+3+4)明显变低,依据I(5+6+7)/I(1+2+3+4)比值可区分癌变与正常组织。31P NMR谱上,癌变组织的最强峰的化学位移明显向高场偏移。(3)在液体1H和31P NMR谱中,1H NMR谱上癌组织中3.20处峰强较正常组织高,表明与癌变密切相关的...; In the present paper, NMR spectroscopy, an effective tool to detect the variation in, molecular structure and changes in chemical composition of metabolites in tissues, was used to study the differences between malignant and normal tissues from rectum. 1H and 31P spectra of seven malignant rectum tissue samples and five normal control tissues were investigated by using a 300 M NMR spectrometers and compared with the results of the infrared spectra of normal and malignant rectum organ tissues. The results indicate that the 1H and 31P spectra of rectum cancer tissues are significantly different from those of the normal controls and most differences present in the form of variation in relative intensities of the characteristic peaks of various metabolites. Systematic differences in the NMR spectra between malignant tissues and normal controls are as follows: in the 1H NMR spectra, differences lie in fatty acids with the concentration of fatty acid decreasing significantly in malignant tissues. In the 31P NMR spectra, differences lie in phospholipid, with the chemical shift of phospholipid decreasing significantly in malignant tissues. This phenomenon may reflect the fact that the activity of protein synthesis is enhanced in cancerous tissues. The difference in the chemical shift of phospholipid between normal rectal tissue and malignant tissue may be considered as a detection criterion. Therefore, the above spectral variations in 31P NMR spectra may be utilized as a potential tool to diagnose rectum cancer.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000264829600024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; SCI(E); EI; PubMed; 中文核心期刊要目总览(PKU); 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 1; 04; 969-973; 29
语种	中文
出处	SCI ; PubMed ; EI ; 万方 ; 知网
出版者	光谱学与光谱分析
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/77905]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	高秀香,姚宏伟,杜俊凯,等. 直肠癌及直肠正常组织的IR和~1H及~(31)P NMR谱研究, Study on malignant and normal rectum tissues using IR and 1H and 31P NMR spectroscopy. 2009-01-01.

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