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	Torque-coupled thermodynamic model for FoF1-ATPase
	Ai, Guangkuo ; Liu, Pengfei ; Ge, Hao
	2017
关键词	F-1-ATPASE MOLECULAR MOTOR ATP SYNTHASE ESCHERICHIA-COLI ENERGY TRANSDUCTION ROTARY MECHANISM ROTATION HYDROLYSIS EFFICIENCY CHEMOMECHANICS STOICHIOMETRY
英文摘要	FoF1-ATPase is a motor protein complex that utilizes transmembrane ion flow to drive the synthesis of adenosine triphosphate (ATP) from adenosine diphosphate (ADP) and phosphate (Pi). While many theoretical models have been proposed to account for its rotary activity, most of them focus on the F-o or F-1 portions separately rather than the complex as a whole. Here, we propose a simple but new torque-coupled thermodynamic model of FoF1-ATPase. Solving this model at steady state, we find that the monotonic variation of each portion's efficiency becomes much more robust over a wide range of parameters when the F-o and F-1 portions are coupled together, as compared to cases when they are considered separately. Furthermore, the coupled model predicts the dependence of each portion's kinetic behavior on the parameters of the other. Specifically, the power and efficiency of the F-1 portion are quite sensitive to the proton gradient across the membrane, while those of the F-o portion as well as the related Michaelis constants for proton concentrations respond insensitively to concentration changes in the reactants of ATP synthesis. The physiological proton gradient across the membrane in the F-o portion is also shown to be optimal for the Michaelis constants of ADP and phosphate in the F-1 portion during ATP synthesis. Together, our coupled model is able to predict key dynamic and thermodynamic features of the FoF1-ATPase in vivo semiquantitatively, and suggests that such coupling approach could be further applied to other biophysical systems.; National Natural Science Foundation of China [21373021, 11622101]; 863 program in China [2015AA020406]; SCI(E); ARTICLE; 5; 95
语种	英语
出处	SCI
出版者	PHYSICAL REVIEW E
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/473337]
专题	数学科学学院
推荐引用方式 GB/T 7714	Ai, Guangkuo,Liu, Pengfei,Ge, Hao. Torque-coupled thermodynamic model for FoF1-ATPase. 2017-01-01.

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