QQ客服 官方微博 反馈留言

	Adiponectin and leptin as first trimester markers for gestational diabetes mellitus: a cohort study
	Thagaard, Ida Naslund ; Krebs, Lone ; Holm, Jens-Christian ; Lange, Theis ; Larsen, Torben ; Christiansen, Michael
	2017
关键词	adiponectin body mass index first trimester screeing gestational diabetes mellitus leptin obesity pregnancy trimester BODY-MASS INDEX RANDOMIZED CONTROLLED-TRIAL MATERNAL SERUM LEPTIN INSULIN-RESISTANCE EARLY-PREGNANCY METABOLIC SYNDROME GLUCOSE-TOLERANCE SUBSEQUENT RISK 2ND TRIMESTER WOMEN
英文摘要	Background: Gestational diabetes mellitus (GDM) is increasing partly due to the obesity epidemic. Adipocytokines have thus been suggested as first trimester screening markers for GDM. In this study we explore the associations between body mass index (BMI) and serum concentrations of adiponectin, leptin, and the adiponectin/ leptin ratio. Furthermore, we investigate whether these markers can improve the ability to screen for GDM in the first trimester. Methods: A cohort study in which serum adiponectin and leptin were measured between gestational weeks 6 + 0 and 14 + 0 in 2590 pregnant women, categorized into normal weight, moderately obese, or severely obese. Results: Lower concentrations of adiponectin were associated with GDM in all BMI groups; the association was more pronounced in BMI < 35 kg/m(2) (p = 0.30 for interaction). Leptin was inversely associated with GDM in severely obese (p = 0.033), but showed no association in women with BMI < 35 kg/m(2). The adiponectin/leptin ratio was associated with GDM in women with BMI < 35 kg/m(2) but not in severely obese women (p = 0.79). In regard to predicting GDM, maternal characteristics combined with adiponectin alone, adiponcetin and leptin, and adiponcetin/ leptin ratio had the strongest associations in women with BMI < 35 kg/m(2). These models had a detection rate of 77.3%-80.3% when the false positive rate was fixed at 25%. Conclusions: Low adiponectin measured in the first trimester is associated with the development of GDM; higher BMI was associated with lower performance of adiponectin, though this was insignificant. Leptin had an inverse relationship with GDM in severely obese women and did not improve the ability to predict GDM.; Region Zealand Health Sciences Research Foundation [15-000342]; Holbaek Hospital; Novo Nordisk Foundation; SCI(E); ARTICLE; 11; 1805-1812; 55
语种	英语
出处	SCI
出版者	CLINICAL CHEMISTRY AND LABORATORY MEDICINE
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/470404]
专题	数学科学学院
推荐引用方式 GB/T 7714	Thagaard, Ida Naslund,Krebs, Lone,Holm, Jens-Christian,et al. Adiponectin and leptin as first trimester markers for gestational diabetes mellitus: a cohort study. 2017-01-01.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。