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	An effective analytic method for detecting tissue-specific genes in RNA-seq experiments
	Zhao, Guoqing ; Li, Qiao ; Wang, I-Ming ; Liu, Xiaoqiao ; Fang, Xiangzhong ; Zhang, Xiaohua Douglas
	2015
关键词	consecutive procedures generalization of Tukey&apos next-generation sequencing RNA-Seq tissue-specific gene IDENTIFYING DIFFERENTIAL EXPRESSION NEGATIVE BINOMIAL DISPERSION SEQUENCE COUNT DATA QUASI-LIKELIHOOD PARAMETER s test
英文摘要	Aim: To develop an analytic method for identifying tissue-specific (TS) genes from RNA-seq data. Materials & methods: Based on a negative binomial distribution, we develop a statistical method containing consecutive procedures incorporating data variability from replicates in each tissue. Results: Simulations show that our approach can effectively identify at least 94% of the truly TS genes if the sample size is 3 and at least 84% of the TS genes detected by our method are truly TS genes. We illustrated the utility of our method in an in-house RNA-seq project and produced sensible results. Conclusion: Our approach not only directly works on discrete data but also naturally incorporates data variability. It works effectively for detecting TS genes.; SCI(E); PubMed; ARTICLE; xiaohua_zhang@merck.com; 16; 1769-1779; 16
语种	英语
出处	SCI ; PubMed
出版者	PHARMACOGENOMICS
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/416909]
专题	数学科学学院
推荐引用方式 GB/T 7714	Zhao, Guoqing,Li, Qiao,Wang, I-Ming,et al. An effective analytic method for detecting tissue-specific genes in RNA-seq experiments. 2015-01-01.

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