QQ客服 官方微博 反馈留言

	Hallmarks of pluripotency
	De Los Angeles, Alejandro ; Ferrari, Francesco ; Xi, Ruibin ; Fujiwara, Yuko ; Benvenisty, Nissim ; Deng, Hongkui ; Hochedlinger, Konrad ; Jaenisch, Rudolf ; Lee, Soohyun ; Leitch, Harry G. ; Lensch, M. William ; Lujan, Ernesto ; Pei, Duanqing ; Rossant, Janet ; Wernig, Marius ; Park, Peter J. ; Daley, George Q.
	2015
关键词	EMBRYONIC STEM-CELLS PRIMORDIAL GERM-CELLS GROUND-STATE PLURIPOTENCY X-CHROMOSOME INACTIVATION DNA METHYLATION TRANSCRIPTIONAL NETWORK REGULATORY CIRCUITRY ISOLATED BLASTOMERES NAIVE PLURIPOTENCY CULTURE-CONDITIONS
英文摘要	Stem cells self-renew and generate specialized progeny through differentiation, but vary in the range of cells and tissues they generate, a property called developmental potency. Pluripotent stem cells produce all cells of an organism, while multipotent or unipotent stem cells regenerate only specific lineages or tissues. Defining stem-cell potency relies upon functional assays and diagnostic transcriptional, epigenetic and metabolic states. Here we describe functional and molecular hallmarks of pluripotent stem cells, propose a checklist for their evaluation, and illustrate how forensic genomics can validate their provenance.; Howard Hughes Medical Institute; SCI(E); PubMed; REVIEW; george.daley@childrens.harvard.edu; 7570; 469-478; 525
语种	英语
出处	PubMed ; SCI
出版者	NATURE
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/416152]
专题	数学科学学院 生命科学学院
推荐引用方式 GB/T 7714	De Los Angeles, Alejandro,Ferrari, Francesco,Xi, Ruibin,et al. Hallmarks of pluripotency. 2015-01-01.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。