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	Integrating Phosphorylation Network with Transcriptional Network Reveals Novel Functional Relationships
	Wang, Lin ; Hou, Lin ; Qian, Minping ; Deng, Minghua
	2012
关键词	SACCHAROMYCES-CEREVISIAE SIGNAL-TRANSDUCTION REGULATORY ASSOCIATIONS PROTEIN-KINASE PATHWAY YEAST KSS1 SPECIFICITY PHOSPHATASE STRESS
英文摘要	Phosphorylation and transcriptional regulation events are critical for cells to transmit and respond to signals. In spite of its importance, systems-level strategies that couple these two networks have yet to be presented. Here we introduce a novel approach that integrates the physical and functional aspects of phosphorylation network together with the transcription network in S. cerevisiae, and demonstrate that different network motifs are involved in these networks, which should be considered in interpreting and integrating large scale datasets. Based on this understanding, we introduce a HeRS score (hetero-regulatory similarity score) to systematically characterize the functional relevance of kinase/phosphatase involvement with transcription factor, and present an algorithm that predicts hetero-regulatory modules. When extended to signaling network, this approach confirmed the structure and cross talk of MAPK pathways, inferred a novel functional transcription factor Sok2 in high osmolarity glycerol pathway, and explained the mechanism of reduced mating efficiency upon Fus3 deletion. This strategy is applicable to other organisms as large-scale datasets become available, providing a means to identify the functional relationships between kinases/phosphatases and transcription factors.; Multidisciplinary Sciences; SCI(E); PubMed; 0; ARTICLE; 3; e33160; 7
语种	英语
出处	PubMed ; SCI
出版者	plos one
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/343446]
专题	数学科学学院
推荐引用方式 GB/T 7714	Wang, Lin,Hou, Lin,Qian, Minping,et al. Integrating Phosphorylation Network with Transcriptional Network Reveals Novel Functional Relationships. 2012-01-01.

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