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	Use of Temporal Morphomic Indices as a Clinically Important Variable in the Diagnosis of Nonsyndromic Craniosynostosis
	Rinkinen, Jacob ; Wang, Lu ; Zhang, Peng ; Lisiecki, Jeffery ; Enchakalody, Binu ; Holcombe, Sven ; Dombrowski, Alex ; Wang, Stewart C. ; Buchman, Steven R. ; Levi, Benjamin
	2014
关键词	craniosynostosis metopic sagittal coronal temporalis muscle temporal fat pad morphomics FORCE-INDUCED CRANIOSYNOSTOSIS MURINE SAGITTAL SUTURE DURA-MATER SARCOPENIA
英文摘要	Introduction: Preoperative computed tomography (CT) evaluation of patients with nonsyndromic craniosynostosis (NSC) has focused on the bony cranial vault while ignoring the surrounding soft tissues. In this study, we posit that novel CT-derived temporal muscle and temporal fat pad morphomics (tissue thickness, area, and volume) can be used to calculate temporal morphomic indices (TMIs), which are unique to each NSC subtype (metopic, coronal, and sagittal) and divergent from normal individuals. Methods: High-throughput image analysis was used to reconstruct the 3-dimensional anatomy and quantify a TMI. These steps were completed in a semiautomated method using algorithms programmed in MATLAB v13.0. Differences in TMI across various craniosynostosis subtypes were assessed using Wilcoxon nonparametric tests for both patients with NSC and a control cohort of patients with trauma. Results: Using preoperative CT images, we evaluated 117 children with NSC from the University of Michigan Health System and 50 age-matched control patients between 1999 and 2011. Results indicate significant differences in TMI among the normal and NSC groups, with normal patients having significantly higher TMI values than patients with metopic, sagittal, and coronal synostosis. In addition, significant differences were found to exist between each craniosynostosis category. Conclusions: Patients with craniosynostosis demonstrate diminished temporalis muscle and overlying fat pad volume and thickness compared with control patients. The unique changes in temporal morphomics presented in this article demonstrate not only that the bony calvaria is affected by craniosynostosis but also that there exist quantifiable aberrations in the temporalis muscle and temporal fat pad. The methodologies described offer a novel methodology to use pre-existing CT scans to glean additional preoperative information on the soft tissue characteristics of patients with craniosynostosis.; Surgery; SCI(E); PubMed; 1; ARTICLE; blevi@umich.edu; 1; 86-91; 73
语种	英语
出处	PubMed ; SCI
出版者	整形外科学纪事
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/342127]
专题	数学科学学院
推荐引用方式 GB/T 7714	Rinkinen, Jacob,Wang, Lu,Zhang, Peng,et al. Use of Temporal Morphomic Indices as a Clinically Important Variable in the Diagnosis of Nonsyndromic Craniosynostosis. 2014-01-01.

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