Bi2S3-Tween 20 Nanodots Loading PI3K Inhibitor, LY294002, for Mild Photothermal Therapy of LoVo Cells In Vitro and In Vivo

doi:10.1002/adhm.201800830

	Bi2S3-Tween 20 Nanodots Loading PI3K Inhibitor, LY294002, for Mild Photothermal Therapy of LoVo Cells In Vitro and In Vivo
	Gu, Z.; Song L(宋丽); Dong XH(董兴华); Zhu S(朱双); Yin WY(尹文艳); Zhang X(张潇); Gu ZJ(谷战军); Song, L.; Dong, X.; Zhu, S.
刊名	ADVANCED HEALTHCARE MATERIALS
	2018
卷号	7 期号:22 页码:1800830
关键词	Bi2S3-Tween 20 nanodots LY294002 mild photothermal therapy photothermal-resistant PI3K inhibitors
ISSN号	2192-2640
DOI	10.1002/adhm.201800830
文献子类	Article
英文摘要	Although various types of photothermal agents are developed for photothermal cancer therapy, relatively few photothermal agents exhibit high tumor inhibition rate under relatively mild conditions. Herein, a multifunctional Bi2S3-Tween 20 nanoplatform loaded with PI3K inhibitor LY294002 is designed as a novel photothermal agent for inhibitor and photothermal synergistic therapy of tumors under mild photothermal therapy conditions. The LY294002 of PI3K inhibitor, after being loaded by Bi2S3-Tween 20 nanodots, exhibits greatly increased drug utilization and reduced side effects on normal tissues. In vivo, Bi2S3-Tween 20@LY294002 upon near-infrared 808 nm laser irradiation shows potent antitumor activity under relatively mild conditions (power density: 0.6 W cm(-2)). Moreover, the mechanism studies also demonstrate that Bi2S3-Tween 20@LY294002 potently kills LoVo cancer cells under low-power near-infrared light irradiation, by downregulating the expression of heat shock protein 70 (HSP70) so as to increase the sensitivity of tumor cell hyperthermia and activating BAX/BAK-regulated mitochondrial apoptosis pathway. The results demonstrate that the newly synthesized multifunctional nanoplatform paves a new avenue for accurate therapy of photothermal-resistant cancer.
电子版国际标准刊号	2192-2659
WOS关键词	DRUG-DELIVERY ; CANCER ; NANOPARTICLES ; NANOSHEETS ; HYPERTHERMIA ; NANOSPHERES ; NANORODS ; 3-KINASE ; CARRIER ; AGENT
WOS研究方向	Engineering ; Science & Technology - Other Topics ; Materials Science
语种	英语
WOS记录号	WOS:000450785100009
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/287006]
专题	高能物理研究所_多学科研究中心高能物理研究所_实验物理中心
通讯作者	Gu ZJ(谷战军)
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Gu, Z.,Song L,Dong XH,et al. Bi2S3-Tween 20 Nanodots Loading PI3K Inhibitor, LY294002, for Mild Photothermal Therapy of LoVo Cells In Vitro and In Vivo[J]. ADVANCED HEALTHCARE MATERIALS,2018,7(22):1800830.
APA	Gu, Z..,宋丽.,董兴华.,朱双.,尹文艳.,...&Liu, X..(2018).Bi2S3-Tween 20 Nanodots Loading PI3K Inhibitor, LY294002, for Mild Photothermal Therapy of LoVo Cells In Vitro and In Vivo.ADVANCED HEALTHCARE MATERIALS,7(22),1800830.
MLA	Gu, Z.,et al."Bi2S3-Tween 20 Nanodots Loading PI3K Inhibitor, LY294002, for Mild Photothermal Therapy of LoVo Cells In Vitro and In Vivo".ADVANCED HEALTHCARE MATERIALS 7.22(2018):1800830.