Gd@C-82(OH)(22) harnesses inflammatory regeneration for osteogenesis of mesenchymal stem cells through JNK/STAT3 signaling pathway

doi:10.1039/c8tb01097h

	Gd@C-82(OH)(22) harnesses inflammatory regeneration for osteogenesis of mesenchymal stem cells through JNK/STAT3 signaling pathway
	Dong JQ(董金泉); Sun, Baoyun; Dong, Jinquan; Zhao, Yuliang; Miao, Qing; Chen, Chunying; Lin, Jiao; Cai, Rong; Sun BY(孙宝云)
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2018
卷号	6 期号:36 页码:5802-5811
ISSN号	2050-750X
DOI	10.1039/c8tb01097h
文献子类	Article
英文摘要	Tissue injuries are inevitably accompanied with immune responses. Understanding the effects of biomaterials on immunology regulation is critical for biomaterial development and tissue regeneration. Inflammatory cytokines secreted from macrophages promote the migration of mesenchymal stem cells (MSCs) to the damaged tissue sites and their subsequent participation in tissue repair. However, the effects of inflammatory cytokines caused by tissue injury on MSC behaviors urgently need to be revealed. Understanding and subsequently manipulating the interactions between immune cells and stem cells will provide us with new therapeutic strategies for tissue regeneration. Nanoparticles having immunomodulatory properties can modulate MSCs' functions in the inflammatory microenvironment. In this study, an immunomodulatory nanoparticle Gd@C-82(OH)(22) was used to manipulate MSC differentiation in inflammatory microenvironment. The results suggested that macrophage-derived inflammation induces osteogenic differentiation of MSCs by activating the JNK/STAT3 pathway. Gd@C-82(OH)(22) modulates inflammation-induced differentiation of MSCs in a dose-dependent manner through the JNK/STAT3 pathway. Low concentration of Gd@C-82(OH)(22) facilitates osteogenesis and high concentration suppresses osteogenesis of hMSCs in the inflammatory microenvironment. This study suggests that Gd@C-82(OH)(22) can act as a promising immunomodulator to differentiate stem cells and improve stem cell-based therapeutic efficiency for biomedical regeneration in inflammatory microenvironments.
电子版国际标准刊号	2050-7518
WOS关键词	OSTEOBLAST DIFFERENTIATION ; TISSUE REGENERATION ; IMMUNE-RESPONSE ; BONE REPAIR ; MACROPHAGES ; NANOPARTICLES ; FRACTURE ; RUNX2 ; MICROENVIRONMENT ; METASTASIS
WOS研究方向	Materials Science
语种	英语
WOS记录号	WOS:000448413200015
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/286620]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Dong JQ,Sun, Baoyun,Dong, Jinquan,et al. Gd@C-82(OH)(22) harnesses inflammatory regeneration for osteogenesis of mesenchymal stem cells through JNK/STAT3 signaling pathway[J]. JOURNAL OF MATERIALS CHEMISTRY B,2018,6(36):5802-5811.
APA	董金泉.,Sun, Baoyun.,Dong, Jinquan.,Zhao, Yuliang.,Miao, Qing.,...&孙宝云.(2018).Gd@C-82(OH)(22) harnesses inflammatory regeneration for osteogenesis of mesenchymal stem cells through JNK/STAT3 signaling pathway.JOURNAL OF MATERIALS CHEMISTRY B,6(36),5802-5811.
MLA	董金泉,et al."Gd@C-82(OH)(22) harnesses inflammatory regeneration for osteogenesis of mesenchymal stem cells through JNK/STAT3 signaling pathway".JOURNAL OF MATERIALS CHEMISTRY B 6.36(2018):5802-5811.