Lipid- and gut microbiota-modulating effects of graphene oxide nanoparticles in high-fat diet-induced hyperlipidemic mice

doi:10.1039/c8ra06058d

	Lipid- and gut microbiota-modulating effects of graphene oxide nanoparticles in high-fat diet-induced hyperlipidemic mice
	Li J(李娟); Yang SM(杨生梅); Cui RL(崔荣丽); Liu R(刘茹); Lei RH(雷润宏); Chang YN(常亚男); Geng H(耿焕); Qin YX(秦艳霞); Gu WH(古伟宏); Xia SB(夏士博)
刊名	RSC ADVANCES
	2018
卷号	8 期号:55 页码:31366-31371
ISSN号	2046-2069
DOI	10.1039/c8ra06058d
文献子类	Article
英文摘要	Graphene oxide (GO) suspensions can act as a good dispersant and drug delivery system for effective dispersion and drug sustained release. In this study, we investigated the impact of GO on blood/liver lipids and gut microbiota structure in high-fat diet (HFD)-induced hyperlipidemic mice. Oral administration of GO for 28 days remarkably decreased the lipid levels in blood and liver. GO did not decrease the total number of gut bacteria but increased the relative abundance of short-chain fatty acid (SCFA)-producing bacteria such as Clostridium clusters IV and Allobaculum spp. GO also enhanced the copying of bacterial butyryl coenzyme A transferase (BcoA), a key butyrate-producing gene. Although further pharmacological studies are still needed, these results provided an interesting hint that GO may exert beneficial effects on the host's metabolism via selective modulation of SCFA-producing gut microbes.
WOS关键词	ANTIMICROBIAL PROPERTIES ; NANOCOMPOSITE FILMS ; EFFICIENT REMOVAL ; MEMBRANES ; NANOSHEETS ; TOXICITY ; BACTERIA ; POLYMER ; NANOTUBES ; MECHANISM
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000445221300015
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/286337]
专题	高能物理研究所_多学科研究中心高能物理研究所_管理与技术支持
通讯作者	Xing GM(邢更妹)
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Li J,Yang SM,Cui RL,et al. Lipid- and gut microbiota-modulating effects of graphene oxide nanoparticles in high-fat diet-induced hyperlipidemic mice[J]. RSC ADVANCES,2018,8(55):31366-31371.
APA	李娟.,杨生梅.,崔荣丽.,刘茹.,雷润宏.,...&Xing, GM.(2018).Lipid- and gut microbiota-modulating effects of graphene oxide nanoparticles in high-fat diet-induced hyperlipidemic mice.RSC ADVANCES,8(55),31366-31371.
MLA	李娟,et al."Lipid- and gut microbiota-modulating effects of graphene oxide nanoparticles in high-fat diet-induced hyperlipidemic mice".RSC ADVANCES 8.55(2018):31366-31371.