A Size-Reducible Nanodrug with an Aggregation-Enhanced Photodynamic Effect for Deep Chemo-Photodynamic Therapy

doi:10.1002/anie.201807602

	A Size-Reducible Nanodrug with an Aggregation-Enhanced Photodynamic Effect for Deep Chemo-Photodynamic Therapy
	Yin WY(尹文艳); Dong XH(董兴华); Gao Q(高琴); Ji, CD; Yin, MZ; Gan, ZH; Zhao, YL; Gu, ZJ; Yin, WY; Dong, XH
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2018
卷号	57 期号:35 页码:11384-11388
关键词	aggregation-enhanced photodynamic effect multifunctionality nanodrugs pentamethine indocyanine size reducibility
ISSN号	1433-7851
DOI	10.1002/anie.201807602
文献子类	Article
英文摘要	Fluorescent dyes with multi-functionality are of great interest for photo-based cancer theranostics. However, their low singlet oxygen quantum yield impedes their potential applications for photodynamic therapy (PDT). Now, a molecular self-assembly strategy is presented for a nanodrug with a remarkably enhanced photodynamic effect based on a dye-chemodrug conjugate. The self-assembled nanodrug possesses an increased intersystem crossing rate owing to the aggregation of dye, leading to a distinct singlet oxygen quantum yield (Phi(O-1(2))). Subsequently, upon red light irradiation, the generated singlet oxygen reduces the size of the nanodrug from 90 to 10 nm, which facilitates deep tumor penetration of the nanodrug and release of chemodrug. The nanodrug achieved insitu tumor imaging and potent tumor inhibition by deep chemo-PDT. Our work verifies a facile and effective self-assembly strategy to construct nanodrugs with enhanced performance for cancer theranostics.
电子版国际标准刊号	1521-3773
WOS关键词	CANCER-THERAPY ; IN-VIVO ; DRUG ; NANOPARTICLES ; TUMOR ; EFFICIENT ; PHOTOSENSITIZERS ; PENETRATION ; COMBINATION ; CONJUGATE
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000442340000048
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/286280]
专题	高能物理研究所_多学科研究中心高能物理研究所_实验物理中心
通讯作者	Yin WY(尹文艳)
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Yin WY,Dong XH,Gao Q,et al. A Size-Reducible Nanodrug with an Aggregation-Enhanced Photodynamic Effect for Deep Chemo-Photodynamic Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(35):11384-11388.
APA	尹文艳.,董兴华.,高琴.,Ji, CD.,Yin, MZ.,...&谷战军.(2018).A Size-Reducible Nanodrug with an Aggregation-Enhanced Photodynamic Effect for Deep Chemo-Photodynamic Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(35),11384-11388.
MLA	尹文艳,et al."A Size-Reducible Nanodrug with an Aggregation-Enhanced Photodynamic Effect for Deep Chemo-Photodynamic Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.35(2018):11384-11388.