Probing Adsorption Behaviors of BSA onto Chiral Surfaces of Nanoparticles

doi:10.1002/smll.201703982

	Probing Adsorption Behaviors of BSA onto Chiral Surfaces of Nanoparticles
	Zhang, D; Wang, MZ; Chen, CY; Wang, XY; Wang XF(王晓峰); Wang, XF; Zhao, YL; Zhu, SF; Lei, R; Liu, T
刊名	SMALL
	2018
卷号	14 期号:16 页码:1703982
关键词	chiral surfaces molecular dynamic simulation nanoparticles protein adsorption behavior
ISSN号	1613-6810
DOI	10.1002/smll.201703982
文献子类	Article
英文摘要	Chiral properties of nanoscale materials are of importance as they dominate interactions with proteins in physiological environments; however, they have rarely been investigated. In this study, a systematic investigation is conducted for the adsorption behaviors of bovine serum albumin (BSA) onto the chiral surfaces of gold nanoparticles (AuNPs), involving multiple techniques and molecular dynamic (MD) simulation. The adsorption of BSA onto both L-and D-chiral surfaces of AuNPs shows discernible differences involving thermodynamics, adsorption orientation, exposed charges, and affinity. As a powerful supplement, MD simulation provides a molecular-level understanding of protein adsorption onto nanochiral surfaces. Salt bridge interaction is proposed as a major driving force at protein-nanochiral interface interaction. The spatial distribution features of functional groups (-COO-, -NH3+, and -CH3) of chiral molecules on the nanosurface play a key role in the formation and location of salt bridges, which determine the BSA adsorption orientation and binding strength to chiral surfaces. Sequentially, BSA corona coated on nanochiral surfaces affects their uptake by cells. The results enhance the understanding of protein corona, which are important for biological effects of nanochirality in living organisms.
电子版国际标准刊号	1613-6829
WOS关键词	GOLD NANOPARTICLES ; PROTEIN CORONA ; CELL-ADHESION ; PLASMONIC NANOSTRUCTURES ; CARBON NANOTUBES ; BLOOD PROTEINS ; ALBUMIN ; SYSTEMS ; SIZE ; CYTOTOXICITY
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
WOS记录号	WOS:000430398600010
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285838]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Zhang, D,Wang, MZ,Chen, CY,et al. Probing Adsorption Behaviors of BSA onto Chiral Surfaces of Nanoparticles[J]. SMALL,2018,14(16):1703982.
APA	Zhang, D.,Wang, MZ.,Chen, CY.,Wang, XY.,王晓峰.,...&Yang, Q.(2018).Probing Adsorption Behaviors of BSA onto Chiral Surfaces of Nanoparticles.SMALL,14(16),1703982.
MLA	Zhang, D,et al."Probing Adsorption Behaviors of BSA onto Chiral Surfaces of Nanoparticles".SMALL 14.16(2018):1703982.