Inhibition of Lysozyme Fibrillation by Gold Nanorods and Nanoparticles

doi:10.1166/jnn.2018.14662

	Inhibition of Lysozyme Fibrillation by Gold Nanorods and Nanoparticles
	Liang, HL; Feng, WY; Zhang, AP; Wang, M; Zheng, LN; Yu, M; Wang, HL; Wang, B; Feng WY(丰伟悦); Wang M(王萌)
刊名	JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
	2018
卷号	18 期号:5 页码:3087-3094
关键词	Gold Nanorods and Nanoparticles Lysozyme Fibrillation Inhibition Effects
ISSN号	1533-4880
DOI	10.1166/jnn.2018.14662
文献子类	Article
英文摘要	Amyloid fibrillation has been implicated in many neurodegenerations, dialysis-related amyloidosis, type II diabetes and more than 30 other amyloid- related diseases. Nanomaterials as potential inhibitors of amyloid fibrillation have attracted increasing interests. In the present study, the effects of gold nanorods (AuNRs) and nanoparticles (AuNPs) on amyloid fibrillation were investigated using hen egg white lysozyme (HEWL) as a model system. Our results indicated that AuNRs and AuNPs, especially AuNRs, present significant inhibitory effects on HEWL amyloid fibril formation during all the kinetic processes, from nucleation to elongation and equilibration stages. The stronger adsorption capacity of HEWL on AuNRs surface is the key mechanism of inhibition of HEWL amyloid fibrillation. Furthermore, AuNRs lead to more stable alpha-helix conformation and hydrophobic microenvironment of aromatic side groups in HEWL molecules, which facilitate the system to form small amorphous aggregates rather than oligomer, profibril or mature fibril.
电子版国际标准刊号	1533-4899
WOS关键词	AMYLOID-BETA OLIGOMERIZATION ; PROTEIN FIBRILLATION ; POLYMERIC NANOPARTICLES ; SIZE ; AGGREGATION ; NUCLEATION ; PATHWAYS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
WOS记录号	WOS:000426040800006
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285685]
专题	高能物理研究所_多学科研究中心
通讯作者	Feng WY(丰伟悦)
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Liang, HL,Feng, WY,Zhang, AP,et al. Inhibition of Lysozyme Fibrillation by Gold Nanorods and Nanoparticles[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2018,18(5):3087-3094.
APA	Liang, HL.,Feng, WY.,Zhang, AP.,Wang, M.,Zheng, LN.,...&汪冰.(2018).Inhibition of Lysozyme Fibrillation by Gold Nanorods and Nanoparticles.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,18(5),3087-3094.
MLA	Liang, HL,et al."Inhibition of Lysozyme Fibrillation by Gold Nanorods and Nanoparticles".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 18.5(2018):3087-3094.