The chemical speciation, spatial distribution and toxicity of mercury from Tibetan medicine Zuotai, beta-HgS and HgCl2 in mouse kidney

doi:10.1016/j.jtemb.2017.08.010

	The chemical speciation, spatial distribution and toxicity of mercury from Tibetan medicine Zuotai, beta-HgS and HgCl2 in mouse kidney
	Chu, SQ; Chu SQ(储胜启); Li, C; Zheng, ZY; Xiao, YC; Li, LS; Bi, HT; Wei, LX; Xu, W; Xu W(徐伟)
刊名	JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
	2018
卷号	45 页码:104-113
关键词	Tibetan medicine Zuotai Mercury X-ray absorption spectroscopy Micro X-ray fluorescence imaging Chemical forms Nephrotoxicity
ISSN号	0946-672X
DOI	10.1016/j.jtemb.2017.08.010
文献子类	Article
英文摘要	Zuotai, a famous Tibetan medicinal mixture containing beta-HgS, has been used to combine with herbal remedies for treating diseases for more than 1 300 years. The target organ for inorganic mercury toxicity is generally considered to be the kidney. Therefore, it is crucial to reveal the chemical speciation, spatial distribution and potential nephrotoxicity of mercury from Zuotai in kidney. To date, this remains poorly understood. We used Xray absorption spectroscopy (XAS) and micro X-ray fluorescence (mu-XRF) imaging based on synchrotron radiation to study mercury chemical forms and mercury special distribution in kidney after mice were treated orally with Zuotai, beta-HgS or HgCl2. Meanwhile, the histopathology of kidney was observed. Mice exposed with Zuotai showed kidney with significant proportion of mercury ions bound to sulfydryl biomolecules (e.g. Cys-S-lig-S-Cys) plus some of unknown species, but without methylmercury cysteine, which is the same as beta-HgS and HgCl2. The mercury is mainly deposited in renal cortex in mouse treated with Zuotai, beta-HgS or HgCl2, but with a low level of mercury in medulla. The total mercury in kidney of mice treated with HgCl2 was much higher than that of beta-HgS, and the later was higher than that of Zuotai. And, HgCl2 cause severe impairments in mouse kidney, but that was not observed in the Zuotai and beta-HgS groups. Meanwhile, the bio-metals (Ca, Zn, Fe and Cu) micro distributions in kidney were also revealed. These findings elucidated the chemical nature, spatial distribution and toxicity difference of mercury from Zuotai, beta-HgS and HgCl2 in mouse kidney, and provide new insights into the appropriate methods for biological monitoring.
WOS关键词	FRESH-WATER SEDIMENTS ; INORGANIC MERCURY ; GENE-EXPRESSION ; MICE ; CHLORIDE ; METHYLMERCURY ; GLUTATHIONE ; LIVER ; ACCUMULATION ; SPECTROMETRY
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种	英语
WOS记录号	WOS:000419812800015
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285531]
专题	高能物理研究所_多学科研究中心高能物理研究所_加速器中心高能物理研究所_粒子天体物理中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Chu, SQ,Chu SQ,Li, C,et al. The chemical speciation, spatial distribution and toxicity of mercury from Tibetan medicine Zuotai, beta-HgS and HgCl2 in mouse kidney[J]. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY,2018,45:104-113.
APA	Chu, SQ.,储胜启.,Li, C.,Zheng, ZY.,Xiao, YC.,...&徐伟.(2018).The chemical speciation, spatial distribution and toxicity of mercury from Tibetan medicine Zuotai, beta-HgS and HgCl2 in mouse kidney.JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY,45,104-113.
MLA	Chu, SQ,et al."The chemical speciation, spatial distribution and toxicity of mercury from Tibetan medicine Zuotai, beta-HgS and HgCl2 in mouse kidney".JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY 45(2018):104-113.