Luminescent, Oxygen-Supplying, Hemoglobin-Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy

doi:10.1002/anie.201905884

CORC > 化学研究所 > 中国科学院化学研究所

	Luminescent, Oxygen-Supplying, Hemoglobin-Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy
	Jiang, Linye; Bai, Haotian; Liu, Libing; Lv, Fengting; Ren, Xueqin; Wang, Shu
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2019-07-29
卷号	58 期号:31 页码:10660-10665
ISSN号	1433-7851
DOI	10.1002/anie.201905884
英文摘要	Photodynamic therapy (PDT) is a promising method for cancer treatment. Two parameters that influence the efficacy of PDT are the light source and oxygen supply. Herein, we prepared a system for PDT using hemoglobin (Hb)-linked conjugated polymer nanoparticles (CPNs), which can luminesce and supply oxygen. Hb catalyzes the activation of luminol, the conjugated polymer poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene] (MEH-PPV) nanoparticles can absorb the chemiluminescence of luminol through chemiluminescence resonance energy transfer (CRET) and then sensitize the oxygen supplied by Hb to produce reactive oxygen species that kill cancer cells. This system could be used for the controlled release of an anticancer prodrug. The system does not need an external light source and circumvents the insufficient level molecular oxygen under hypoxia. This work provides a proof-of-concept to explore smart and multifunctional nanoplatforms for phototherapy.
语种	英语
WOS记录号	WOS:000476919100043
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/82719]
专题	中国科学院化学研究所
作者单位	Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Linye,Bai, Haotian,Liu, Libing,et al. Luminescent, Oxygen-Supplying, Hemoglobin-Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(31):10660-10665.
APA	Jiang, Linye,Bai, Haotian,Liu, Libing,Lv, Fengting,Ren, Xueqin,&Wang, Shu.(2019).Luminescent, Oxygen-Supplying, Hemoglobin-Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(31),10660-10665.
MLA	Jiang, Linye,et al."Luminescent, Oxygen-Supplying, Hemoglobin-Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.31(2019):10660-10665.