MnFe2O4-decorated large-pore mesoporous silica-coated upconversion nanoparticles for near-infrared light-induced and O-2 self-sufficient photodynamic therapy

doi:10.1039/c9nr04858h

CORC > 化学研究所 > 中国科学院化学研究所

	MnFe2O4-decorated large-pore mesoporous silica-coated upconversion nanoparticles for near-infrared light-induced and O-2 self-sufficient photodynamic therapy
	Ding, Binbin; Shao, Shuai; Xiao, Haihua; Sun, Chunqiang; Cai, Xuechao; Jiang, Fan; Zhao, Xueyan; Ma, Ping'an; Lin, Jun
刊名	NANOSCALE
	2019-08-21
卷号	11 期号:31 页码:14654-14667
ISSN号	2040-3364
DOI	10.1039/c9nr04858h
英文摘要	The limited light penetration depth and tumor hypoxia are two natural shortcomings of photodynamic therapy (PDT). Overcoming these two issues within a single system is still a great challenge. Herein, photosensitizer (PS)-loaded and PEG-modified MnFe2O4-decorated large-pore mesoporous silica-coated beta-NaYF4:20%Yb,2%Er@beta-NaYF4 upconversion nanoparticles (UCMnFe-PS-PEG) as excellent PDT agents are successfully prepared for NIR light-mediated and O-2 self-sufficient PDT. The large mesoporous structure observably increases PS loading efficiency (11.33 wt%) and the green luminescence from upconversion nanoparticles activated by NIR is able to activate PSs to generate ROS effectively. In addition, sub-10 nm MnFe2O4 nanoparticles work as a Fenton catalyst to generate O(2)in situ. In vivo experiments further prove that UCMnFe-PS-PEG not only provides magnetic guidance to the tumor, but also overcomes tumor hypoxia and dramatically enhances PDT efficiency. Furthermore, in vivo MR and UCL imaging are performed for accurate cancer therapy. We believe that the successful construction of the multifunctional UCMnFe-PS-PEG provides more revelations for developing advanced nano-drug systems for cancer therapy.
语种	英语
WOS记录号	WOS:000484297400013
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/82642]
专题	中国科学院化学研究所
作者单位	Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Ding, Binbin,Shao, Shuai,Xiao, Haihua,et al. MnFe2O4-decorated large-pore mesoporous silica-coated upconversion nanoparticles for near-infrared light-induced and O-2 self-sufficient photodynamic therapy[J]. NANOSCALE,2019,11(31):14654-14667.
APA	Ding, Binbin.,Shao, Shuai.,Xiao, Haihua.,Sun, Chunqiang.,Cai, Xuechao.,...&Lin, Jun.(2019).MnFe2O4-decorated large-pore mesoporous silica-coated upconversion nanoparticles for near-infrared light-induced and O-2 self-sufficient photodynamic therapy.NANOSCALE,11(31),14654-14667.
MLA	Ding, Binbin,et al."MnFe2O4-decorated large-pore mesoporous silica-coated upconversion nanoparticles for near-infrared light-induced and O-2 self-sufficient photodynamic therapy".NANOSCALE 11.31(2019):14654-14667.