Dietary protein levels regulated antibacterial activity, inflammatory response and structural integrity in the head kidney, spleen and skin of grass carp (Ctenopharyngodon idella) after challenged with Aeromonas hydrophila | |
Jiang, Wei-Dan1,2,3; Xu, Jing1; Zhou, Xiao-Qiu1,2,3; Wu, Pei1,2,3; Liu, Yang1,2,3; Jiang, Jun1,2,3; Kuang, Sheng-Yao4; Tang, Ling4; Tang, Wu-Neng4; Zhang, Yong-An5 | |
刊名 | FISH & SHELLFISH IMMUNOLOGY |
2017-09-01 | |
卷号 | 68期号:1页码:154-172 |
关键词 | Protein Grass carp (Ctenopharyngodon idella) Disease resistance Immune function Structural integrity |
ISSN号 | 1050-4648 |
DOI | 10.1016/j.fsi.2017.07.019 |
英文摘要 | This study investigated the effects of dietary protein levels on disease resistance, immune function and structural integrity in the head kidney, spleen and skin of grass carp (Ctenopharyngodon idella). A total of 540 grass carp (264.11 +/- 0.76 g) were fed six diets containing graded levels of protein (143.1,176.7, 217.2, 257.5, 292.2 and 322.8 g digestible protein kg(-1) diet) for 8 weeks. After the growth trial, fish were challenged with Aeromonas hydrophila for 14 days. The results indicated that optimal levels of dietary protein: (1) (1) increased the lysozyme (LA) and acid phosphatase (ACP) activities and the complement 3 (C3) and C4 contents, up-regulated antimicrobial peptides, anti-inflammatory cytokines, inhibitor of kappa B alpha, target of rapamycin and ribosomal protein S6 kinases 1 mRNA levels, whereas down-regulated pro-inflammatory cytokines, nuclear factor kappa B (NF-kappa B) P65, IKK beta, IKK gamma, eIF4E-binding proteins (4E-BP) 1 and 4E-BP2 mRNA levels in the head kidney, spleen and skin of grass carp (P < 0.05), suggesting that optimal level of dietary protein could enhance immune function in the head kidney, spleen and skin of fish; (2) increased the activities and mRNA levels of antioxidant enzymes, enhanced the glutathione content, decreased reactive oxygen species, malondialdehyde (MDA) and protein carbonyl contents, and up-regulated the mRNA levels of NF-E2-related factor 2, B-cell lymphoma protein-2, inhibitor of apoptosis proteins, myeloid cell leukemia-1 and tight junction complexes, whereas down-regulated Kelch-like-ECH-associated protein (Keap) 1b, cysteinyl aspartic acid-protease 3, 8, 9, Fas ligand, apoptotic protease activating factor-1, Bcl-2 associated X protein and myosin light chain kinase mRNA levels in the head kidney, spleen and skin of grass carp (P < 0.05), indicating that optimal level of dietary protein could improve structural integrity in the head kidney, spleen and skin of fish. Finally, based on the skin hemorrhage and lesion morbidity, LA activity and MDA content, the optimal levels of dietary protein for grass carp (264 g-787 g) were estimated to be 241.45 g kg(-1) diet (217.68 g digestible protein kg(-1) diet), 301.68 g kg(-1) diet (265.48 g digestible protein kg(-1) diet) and 307.84 g kg(-1) diet (272.71 g digestible protein kg(-1) diet), respectively. (C) 2017 Published by Elsevier Ltd. |
资助项目 | National Basic Research Program of China (973 Program)[2014CB138600] ; National Natural Science Foundation of China[31672662] ; National Natural Science Foundation of China[31572632] ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture) ; National Department Public Benefit Research Foundation (Agriculture) of China[201003020] ; Science and Technology Support Program of Sichuan Province of China[2014NZ0003] ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2012NC0007] ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2013NC0045] ; Foundation of Sichuan Youth Science and Technology Innovation Research Team[2017TD0002] ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2015CC0011] ; Natural Science Foundation[2014JQ0007] |
WOS关键词 | NF-KAPPA-B ; PHYSICAL BARRIER FUNCTION ; TIGHT JUNCTION PROTEINS ; INTESTINAL MUCOSAL IMMUNE ; TROUT ONCORHYNCHUS-MYKISS ; MESSENGER-RNA EXPRESSION ; MLCK SIGNALING PATHWAYS ; FISH GILTHEAD SEABREAM ; GENE-EXPRESSION ; TRANSCRIPT ABUNDANCE |
WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
语种 | 英语 |
出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000411299500017 |
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内容类型 | 期刊论文 |
源URL | [http://ir.ihb.ac.cn/handle/342005/32713] |
专题 | 水生生物研究所_中科院水生所知识产出(2009年前) |
通讯作者 | Feng, Lin |
作者单位 | 1.Sichuan Agr Univ, Anim Nutr Inst, Chengdu 611130, Sichuan, Peoples R China 2.Sichuan Agr Univ, Fish Nutr & Safety Prod Univ, Key Lab Sichuan Prov, Chengdu 611130, Sichuan, Peoples R China 3.Sichuan Agr Univ, Key Lab Anim Dis Resistance Nutr, China Minist Educ, Chengdu 611130, Sichuan, Peoples R China 4.Sichuan Acad Anim Sci, Anim Nutr Inst, Chengdu 610066, Sichuan, Peoples R China 5.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Jiang, Wei-Dan,Xu, Jing,Zhou, Xiao-Qiu,et al. Dietary protein levels regulated antibacterial activity, inflammatory response and structural integrity in the head kidney, spleen and skin of grass carp (Ctenopharyngodon idella) after challenged with Aeromonas hydrophila[J]. FISH & SHELLFISH IMMUNOLOGY,2017,68(1):154-172. |
APA | Jiang, Wei-Dan.,Xu, Jing.,Zhou, Xiao-Qiu.,Wu, Pei.,Liu, Yang.,...&Feng, Lin.(2017).Dietary protein levels regulated antibacterial activity, inflammatory response and structural integrity in the head kidney, spleen and skin of grass carp (Ctenopharyngodon idella) after challenged with Aeromonas hydrophila.FISH & SHELLFISH IMMUNOLOGY,68(1),154-172. |
MLA | Jiang, Wei-Dan,et al."Dietary protein levels regulated antibacterial activity, inflammatory response and structural integrity in the head kidney, spleen and skin of grass carp (Ctenopharyngodon idella) after challenged with Aeromonas hydrophila".FISH & SHELLFISH IMMUNOLOGY 68.1(2017):154-172. |
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