Organocatalytic Enantioselective Hydroxymethylation of Oxindoles with Paraformaldehyde as C1 Unit

	Organocatalytic Enantioselective Hydroxymethylation of Oxindoles with Paraformaldehyde as C1 Unit
	Liu, Xiong-Li ; Liao, Yu-Hua ; Wu, Zhi-Jun ; Cun, Lin-Feng ; Zhang, Xiao-Mei ; Yuan, Wei-Cheng
刊名	JOURNAL OF ORGANIC CHEMISTRY
	2010
卷号	75 期号:14 页码:4872-4875
ISSN号	0022-3263
通讯作者	Yuan, WC, Chinese Acad Sci, Chengdu Inst Organ Chem, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Chengdu 610041, Peoples R China
产权排序	2
中文摘要	A bifunctional thiourea-tertiary amine-catalyzed asymmetric hydroxymethylation of 3-substituted oxindoles using paraformaldehyde as the C1 unit was developed. A wide scope of oxindoles, bearing C3 sterically congested quaternary carbon centers, were smoothly obtained in good to excellent yields (up to 99%) and high enantioselectivities (up to 91% ee) under mild reaction conditions. A more significant feature of this approach employs cheap and readily available paraformaldehyde as a hydroxymethylation Cl unit, which is activated by chiral bifunctional thiourea organocatalysts.
学科主题	Chemistry, Organic
收录类别	SCI
资助信息	National Natural Science Foundation of China [20802074]; National Basic Research Program of China (973 Program) [2010CB833300]
语种	英语
WOS记录号	WOS:000279569500028
公开日期	2011-07-08
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/18415]
专题	成都生物研究所_天然产物研究
推荐引用方式 GB/T 7714	Liu, Xiong-Li,Liao, Yu-Hua,Wu, Zhi-Jun,et al. Organocatalytic Enantioselective Hydroxymethylation of Oxindoles with Paraformaldehyde as C1 Unit[J]. JOURNAL OF ORGANIC CHEMISTRY,2010,75(14):4872-4875.
APA	Liu, Xiong-Li,Liao, Yu-Hua,Wu, Zhi-Jun,Cun, Lin-Feng,Zhang, Xiao-Mei,&Yuan, Wei-Cheng.(2010).Organocatalytic Enantioselective Hydroxymethylation of Oxindoles with Paraformaldehyde as C1 Unit.JOURNAL OF ORGANIC CHEMISTRY,75(14),4872-4875.
MLA	Liu, Xiong-Li,et al."Organocatalytic Enantioselective Hydroxymethylation of Oxindoles with Paraformaldehyde as C1 Unit".JOURNAL OF ORGANIC CHEMISTRY 75.14(2010):4872-4875.