Crosslinking of viral nanoparticles with "clickable" fluorescent crosslinkers at the interface

	Crosslinking of viral nanoparticles with "clickable" fluorescent crosslinkers at the interface
	Kaur, Gagandeep ; Zhan WenHai ; Wang Chao ; Barnhill, Hannah ; Tian He ; Wang Qian
刊名	SCIENCE CHINA-CHEMISTRY
	2010
卷号	53 期号:6 页码:1287-1293
关键词	pickering emulsion crosslinking nanoparticles CuAAC reaction click chemistry interfacial assembly
ISSN号	1674-7291
通讯作者	Tian, H, E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China
产权排序	3
中文摘要	Cu (I) catalyzed alkyne-azide cycloaddition (CuAAC) reaction, a typical "click" reaction, is one of the modular synthetic approaches which has been broadly used in various organic syntheses, medicinal chemistry, materials development and bioconjugation applications. We have for the first time synthesized two dialkyne derivatized fluorescent crosslinkers which could be applied to crosslink two biomolecules using CuAAC reaction. Turnip yellow mosaic virus, a plant virus with unique structural and chemical properties, was used as a prototypical scaffold to form a 2D single layer at the interface of two immiscible liquids and crosslinked with these two linkers by the CuAAC reaction. Upon crosslinking, the fluorescence of both linkers diminished, likely due to the distortion of the polymethylene backbone, which therefore could be used to indicate the completion of the reaction.
学科主题	Chemistry, Multidisciplinary
收录类别	SCI
资助信息	US NSF [CHE-0748690]; US DoD-ARO [W911NF-09-1-0236]; W. M. Keck Foundation ; Camille Dreyfus Teacher-Scholarship ; Alfred P. Sloan Foundation ; National Natural Science Foundation of China [50673025]; National Basic Research 973 Program [2006CB806200]; US DoE
语种	英语
WOS记录号	WOS:000279240100009
公开日期	2011-07-08
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/18381]
专题	成都生物研究所_天然产物研究
推荐引用方式 GB/T 7714	Kaur, Gagandeep,Zhan WenHai,Wang Chao,et al. Crosslinking of viral nanoparticles with "clickable" fluorescent crosslinkers at the interface[J]. SCIENCE CHINA-CHEMISTRY,2010,53(6):1287-1293.
APA	Kaur, Gagandeep,Zhan WenHai,Wang Chao,Barnhill, Hannah,Tian He,&Wang Qian.(2010).Crosslinking of viral nanoparticles with "clickable" fluorescent crosslinkers at the interface.SCIENCE CHINA-CHEMISTRY,53(6),1287-1293.
MLA	Kaur, Gagandeep,et al."Crosslinking of viral nanoparticles with "clickable" fluorescent crosslinkers at the interface".SCIENCE CHINA-CHEMISTRY 53.6(2010):1287-1293.