Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp SOF07

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp SOF07
	jju@scsio.ac.cn; Chen, ZM; Zheng, ZH; Huang, HB; Song, YX; Zhang, XL; Ma, JY; Wang, B; Zhang, CS; Ju, JH
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2012
卷号	22 期号:9 页码:3332-3335
关键词	Marine Fungi Penicillium Sp. Penicacid A-c Inosine-monophosphate Dehydrogenase Structure-activity Relationship
ISSN号	0960-894X
英文摘要	Three new mycophenolic acid derivatives, penicacids A-C (1-3), together with two known analogues, mycophenolic acid (MPA, 4) and 4'-hydroxy-MPA (5), were isolated from a fungus Penicillium sp. SOF07 derived from a South China Sea marine sediment. The structures of compounds 1-3 were elucidated on the basis of MS and NMR (H-1, C-13, HSQC and HMBC) data analyses and comparisons with the known compounds. Structure-activity relationship studies of compounds 1-5 focused on inosine-monophosphate dehydrogenase inhibition revealed that hydroxylation at C-4', methylation at C-7-OH, dual hydroxylation at C-2'/C-3' double bond of MPA diminished bioactivity whereas glucosyl hydroxylation at C-4' correlated to bioactivity comparable to that observed for MPA. (C) 2012 Elsevier Ltd. All rights reserved.
学科主题	Chemistry, Medicinal ; Chemistry, Organic
资助项目	LMB
语种	英语
WOS记录号	WOS:000302964300059
公开日期	2013-08-28
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/9928]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
通讯作者	jju@scsio.ac.cn
推荐引用方式 GB/T 7714	jju@scsio.ac.cn,Chen, ZM,Zheng, ZH,et al. Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp SOF07[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(9):3332-3335.
APA	jju@scsio.ac.cn.,Chen, ZM.,Zheng, ZH.,Huang, HB.,Song, YX.,...&Ju, JH.(2012).Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp SOF07.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(9),3332-3335.
MLA	jju@scsio.ac.cn,et al."Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp SOF07".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.9(2012):3332-3335.