Molecular cloning, characterization and expression analysis of tumor necrosis factor receptor-associated factor 3 (TRAF3) from pearl oyster Pinctada fucata

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	Molecular cloning, characterization and expression analysis of tumor necrosis factor receptor-associated factor 3 (TRAF3) from pearl oyster Pinctada fucata
	Huang, XD; Liu, WG; Guan, YY; He, MX; Shi, Y; Wang, Q; Zhao, M; Wu, SZ; hmx@scsio.ac.cn
刊名	FISH & SHELLFISH IMMUNOLOGY
	2012
卷号	33 期号:3 页码:652-658
关键词	Pearl Oyster Pftraf3 Immune Response Vibrio Alginolyticus
ISSN号	1050-4648
英文摘要	TRAF3 is a highly versatile regulator that negatively regulates JNK and alternative nuclear factor-kappa B signalling, but positively controls type I interferon production. To investigate TRAF3 function in innate immune responses among invertebrate especially mollusk, we characterized TRAF3 (PfTRAF3) from pearl oyster Pinctada fucata, one of the most important bivalve mollusks for seawater pearl production. PfTRAF3 cDNA is 2261 bp with an open reading frame of 1623 bp encoding a putative protein of 541 amino acids. The deduced PfTRAF3 contains a RING finger domain, two TRAF domains with zinc finger domains and a conserved C-terminal meprin and TRAF homology (MATH) domain. Comparison and phylogenetic analysis revealed that PfTRAF3 from mollusk shared a higher identity with Ciona intestinalis TRAF3 from urochordata, Branchiostoma belcheri TRAF3 from cephalochordate, and even TRAF3 from vertebrate than with insect homologues. Furthermore, gene expression analyses suggested that PfTRAF3 was involved in the immune response to Vibrio alginolyticus. (C) 2012 Elsevier Ltd. All rights reserved.
学科主题	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
资助项目	LMB
语种	英语
WOS记录号	WOS:000308057700024
公开日期	2013-08-28
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/9820]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
通讯作者	hmx@scsio.ac.cn
推荐引用方式 GB/T 7714	Huang, XD,Liu, WG,Guan, YY,et al. Molecular cloning, characterization and expression analysis of tumor necrosis factor receptor-associated factor 3 (TRAF3) from pearl oyster Pinctada fucata[J]. FISH & SHELLFISH IMMUNOLOGY,2012,33(3):652-658.
APA	Huang, XD.,Liu, WG.,Guan, YY.,He, MX.,Shi, Y.,...&hmx@scsio.ac.cn.(2012).Molecular cloning, characterization and expression analysis of tumor necrosis factor receptor-associated factor 3 (TRAF3) from pearl oyster Pinctada fucata.FISH & SHELLFISH IMMUNOLOGY,33(3),652-658.
MLA	Huang, XD,et al."Molecular cloning, characterization and expression analysis of tumor necrosis factor receptor-associated factor 3 (TRAF3) from pearl oyster Pinctada fucata".FISH & SHELLFISH IMMUNOLOGY 33.3(2012):652-658.