Fluostatins I-K from the South China Sea-Derived Micromonospora rosaria SCSIO N160

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	Fluostatins I-K from the South China Sea-Derived Micromonospora rosaria SCSIO N160
	Zhang, CS; Zhang, WJ; Liu, Z; Li, SM; Lu, YZ; czhang2006@gmail.com; Chen, YC; Zhang, HB; Zhang, GT; Zhu, YG
刊名	JOURNAL OF NATURAL PRODUCTS
	2012
卷号	75 期号:11 页码:1937-1943
ISSN号	0163-3864
英文摘要	The strain SCSIO N160 was isolated from a South China Sea sediment sample and was characterized as a Micromonospora rosaria species on the basis of its 16S rRNA gene sequence. Three new fluostatins, I-K (1-3), were isolated from the culture of M rosaria SCSIO N160, together with six known compounds, fluostatins C-F (4-7), rabelomycin (8), and phenanthroviridone (9). The structure of fluostatin D (5) was confirmed by an X-ray crystallographic study. The absolute configuration of 1 and 3 was assigned by electronic circular dichroism calculations. Compounds 8 and 9 exhibited good antimicrobial activities against Staphylococcus aureus ATCC 29213 with MIC values of 1.0 and 0.25 mu g/mL, respectively. Compound 9 also exhibited significant in vitro cytotoxic activities toward SF-268 (IC50 0.09 mu M) and MCF-7 (IC50 0.17 mu M).
学科主题	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
资助项目	LMB
语种	英语
WOS记录号	WOS:000311461300010
公开日期	2013-08-28
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/9756]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
通讯作者	czhang2006@gmail.com
推荐引用方式 GB/T 7714	Zhang, CS,Zhang, WJ,Liu, Z,et al. Fluostatins I-K from the South China Sea-Derived Micromonospora rosaria SCSIO N160[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(11):1937-1943.
APA	Zhang, CS.,Zhang, WJ.,Liu, Z.,Li, SM.,Lu, YZ.,...&Liu, JS.(2012).Fluostatins I-K from the South China Sea-Derived Micromonospora rosaria SCSIO N160.JOURNAL OF NATURAL PRODUCTS,75(11),1937-1943.
MLA	Zhang, CS,et al."Fluostatins I-K from the South China Sea-Derived Micromonospora rosaria SCSIO N160".JOURNAL OF NATURAL PRODUCTS 75.11(2012):1937-1943.