Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus

doi:10.1021/acs.jnatprod.8b00753

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus
	Xue, Jiao ; Qu, Xudong ; Hu, Yunfeng 2; Deng, Zixin ; Bi, Hongkai 1; Qiao, Yongjian ; Yan, Jiayan ; Jia, Jia 1; Zhu, Dongqing
刊名	JOURNAL OF NATURAL PRODUCTS
	2019
卷号	82 期号:2 页码:318
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.8b00753
英文摘要	Armeniaspirols (1-3) are potent antibiotics against Gram-positive pathogens. Through a biosynthetic investigation, we identified four enzymes involved in the structural modification of 1-3. Manipulation of their activity led to the generation of 4-6 and nine novel analogues, 7-15. Bioactivity assessments revealed that the pyrrole chloro group and the methyl group are important for the antimicrobial activities of armeniaspirols, which lays the foundation for future structure optimization and mechanism of action studies of armeniaspirols.
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/17906]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.Wuhan Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Hubei, Peoples R China 2.Nanjing Med Univ, Dept Pathogen Biol, Nanjing 210029, Jiangsu, Peoples R China 3.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Xue, Jiao,Qu, Xudong,Hu, Yunfeng,et al. Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(2):318, 323.
APA	Xue, Jiao.,Qu, Xudong.,Hu, Yunfeng.,Deng, Zixin.,Bi, Hongkai.,...&Zhu, Dongqing.(2019).Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus.JOURNAL OF NATURAL PRODUCTS,82(2),318.
MLA	Xue, Jiao,et al."Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus".JOURNAL OF NATURAL PRODUCTS 82.2(2019):318.