AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis

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	AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis
	Tu, Jiajia ; Yao, Ziwei 2; Ding, Wenjuan 2; Li, Qinglian ; Wang, Liyan 3; Huang, Hongbo ; Li, Shengying 1; Ju, Jianhua 2
刊名	ORGANIC LETTERS
	2018
卷号	20 期号:16 页码:4854
ISSN号	1523-7060
英文摘要	Members of the abyssomicin class of natural products are characterized by a novel vinylic bridged ether ring. In this study, in vivo gene inactivation, structure elucidation of the accumulated intermediate abyssomicin 6, and in vitro enzyme assays enabled the identification of a cytochrome P450 enzyme, AbmV. AbmV carries out domino reactions involving bridged ether installation and C-11 hydroxylation during the biosynthesis of neoabyssomicins/abyssomicins in S. koyangensis SCSIO 5802.
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/17645]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.Shenzhen Univ, Coll Bio & Marine Sci, 3688 Nanhai Ave, Shenzhen 518060, Peoples R China 2.Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China 3.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Prov Key Lab Synthet Biol, CAS Key Lab Biofuels, Qingdao 266000, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Tu, Jiajia,Yao, Ziwei,Ding, Wenjuan,et al. AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis[J]. ORGANIC LETTERS,2018,20(16):4854, 4857.
APA	Tu, Jiajia.,Yao, Ziwei.,Ding, Wenjuan.,Li, Qinglian.,Wang, Liyan.,...&Ju, Jianhua.(2018).AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis.ORGANIC LETTERS,20(16),4854.
MLA	Tu, Jiajia,et al."AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis".ORGANIC LETTERS 20.16(2018):4854.