Marine Bacterial Aromatic Polyketides From Host-Dependent Heterologous Expression and Fungal Mode of Cyclization

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	Marine Bacterial Aromatic Polyketides From Host-Dependent Heterologous Expression and Fungal Mode of Cyclization
	Zhang, Changsheng 1; Huang, Chunshuai 1; Yang, Chunfang ; Zhu, Yiguang ; Zhang, Wenjun ; Yuan, Chengshan
刊名	FRONTIERS IN CHEMISTRY
	2018
卷号	6 页码:528
关键词	heterologous expression aromatic polyketides type II polyketide synthase cyclization modes pathway crosstalk
ISSN号	2296-2646
英文摘要	The structure diversity of type II polyketide synthases-derived bacterial aromatic polyketides is often enhanced by enzyme controlled or spontaneous cyclizations. Here we report the discovery of bacterial aromatic polyketides generated from 5 different cyclization modes and pathway crosstalk between the host and the heterologous fluostatin biosynthetic gene cluster derived from a marine bacterium. The discovery of new compound SEK43F (2) represents an unusual carbon skeleton resulting from a pathway crosstalk, in which a pyrrole-like moiety derived from the host Streptomyces albus J1074 is fused to an aromatic polyketide SEK43 generated from the heterologous fluostatin type II PKSs. The occurrence of a new congener, fluoquinone (3), highlights a bacterial aromatic polyketide that is exceptionally derived from a characteristic fungal F-mode first-ring cyclization. This study expands our knowledge on the power of bacterial type II PKSs in diversifying aromatic polyketides.
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/17620]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.Chinese Acad Sci, RNAM Ctr Marine Microbiobgy, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, Guangzhou, Guangdong, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Changsheng,Huang, Chunshuai,Yang, Chunfang,et al. Marine Bacterial Aromatic Polyketides From Host-Dependent Heterologous Expression and Fungal Mode of Cyclization[J]. FRONTIERS IN CHEMISTRY,2018,6:528.
APA	Zhang, Changsheng,Huang, Chunshuai,Yang, Chunfang,Zhu, Yiguang,Zhang, Wenjun,&Yuan, Chengshan.(2018).Marine Bacterial Aromatic Polyketides From Host-Dependent Heterologous Expression and Fungal Mode of Cyclization.FRONTIERS IN CHEMISTRY,6,528.
MLA	Zhang, Changsheng,et al."Marine Bacterial Aromatic Polyketides From Host-Dependent Heterologous Expression and Fungal Mode of Cyclization".FRONTIERS IN CHEMISTRY 6(2018):528.