QQ客服 官方微博 反馈留言

	Early embryonic exposure of ionizing radiations disrupts zebrafish pigmentation
	Wang, Yupei1,2,3,4; Zhou, Xin5; Zhao, Baoquan6; Ren, Xiaotang7; Chen, Yuhong1,2,3,4; Si, Jing1,2,3; Zhou, Rong1,2,3; Gan, Lu1,2,3; Zhang, Hong1,2,3,8
刊名	JOURNAL OF CELLULAR PHYSIOLOGY
	2019
卷号	234期号:1页码:940-949
关键词	ATP synthase ionizing radiation pigmentation zebrafish
ISSN号	0021-9541
DOI	10.1002/jcp.26922
通讯作者	Zhang, Hong(zhangh@impcas.ac.cn)
英文摘要	Studies have demonstrated that zebrafish are powerful tools for monitoring environmental toxicity, including radiation hazard. Here we investigated the developmental toxicity of ionizing radiation (IR) in an in vivo embryonic zebrafish model. The effects of heavy ion (C-12(6+)), proton, and X-ray radiation on early zebrafish embryos were determined. A similar dose-dependent decrease in the hatch and survival rate of zebrafish embryos was observed after exposure to these irradiations. Exposure of zebrafish embryos to 1-4 Gy IR caused significant loss of pigmentation. Quantitative real-time reverse transcription polymerase chain reaction, western blot analysis, and in situ hybridization (ISH) experiment revealed that atp5 alpha 1 was markedly upregulated in irradiated zebrafish embryos. In addition, IR resulted in a rapid decrease in total adenosine triphosphate (ATP) generation. With dual functions of synthesizing or hydrolyzing ATP, ATP synthase regulated H+ transport crossing the mitochondrial inner. Administration of the mitochondrial ATP synthase inhibitor, oligomycin, partially restored pigmentation in irradiated zebrafish embryos, but the ATPase inhibitor, BTB06584, had no effect. Taken together, these results showed that IR exposure downregulated zebrafish pigmentation through regulation of H+ ion transport in mitochondria.
收录类别	SCI
WOS关键词	GAMMA-IRRADIATION ; EXPRESSION ; IDENTIFICATION ; ACCIDENT ; ATPASE ; GENES ; CELLS ; MODEL
WOS研究方向	Cell Biology ; Physiology
WOS类目	Cell Biology ; Physiology
语种	英语
出版者	WILEY
WOS记录号	WOS:000451533300079
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2558244
专题	寒区旱区环境与工程研究所
通讯作者	Zhang, Hong
作者单位	1.Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Gansu, Peoples R China 3.Inst Modern Phys, Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 5.Umea Univ, Dept Med Biochem & Biophys, Umea, Sweden 6.Acad Mil Med Sci, Inst Pharmacol & Toxicol, State Key Lab Toxicol & Med Countermeasures, Beijing, Peoples R China 7.Peking Univ, State Key Lab Nucl Phys & Technol, Beijing, Peoples R China 8.Gansu Wuwei Tumor Hosp, Wuwei, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yupei,Zhou, Xin,Zhao, Baoquan,et al. Early embryonic exposure of ionizing radiations disrupts zebrafish pigmentation[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2019,234(1):940-949.
APA	Wang, Yupei.,Zhou, Xin.,Zhao, Baoquan.,Ren, Xiaotang.,Chen, Yuhong.,...&Zhang, Hong.(2019).Early embryonic exposure of ionizing radiations disrupts zebrafish pigmentation.JOURNAL OF CELLULAR PHYSIOLOGY,234(1),940-949.
MLA	Wang, Yupei,et al."Early embryonic exposure of ionizing radiations disrupts zebrafish pigmentation".JOURNAL OF CELLULAR PHYSIOLOGY 234.1(2019):940-949.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。