| A Comprehensive RNA Expression Signature for Cervical Squamous Cell Carcinoma Prognosis | |
| Xiong, Jie1; Guo, Shengyu1; Bing, Zhitong2; Su, Yanlin3; Guo, Le4 | |
| 刊名 | FRONTIERS IN GENETICS
 |
| 2019-01-04 | |
| 卷号 | 9页码:12 |
| 关键词 | transcriptome signature prognosis CESC angiogenesis |
| ISSN号 | 1664-8021 |
| DOI | 10.3389/fgene.2018.00696 |
| 通讯作者 | Xiong, Jie(xiongjie86@126.com) |
| 英文摘要 | Clinicopathological characteristics alone are not enough to predict the survival of patients with cervical squamous cell carcinoma (CESC) due to clinical heterogeneity. In recent years, many genes and non-coding RNAs have been shown to be oncogenes or tumor-suppressors in CESC cells. This study aimed to develop a comprehensive transcriptomic signature for CESC patient prognosis. Univariate, multivariate, and Least Absolute Shrinkage and Selection Operator penalized Cox regression were used to identify prognostic signatures for CESC patients from transcriptomic data of The Cancer Genome Atlas. A normalized prognostic index (NPI) was formulated as a synthetical index for CESC prognosis. Time-dependent receiver operating characteristic curve analysis was used to compare prognostic signatures. A prognostic transcriptomic signature was identified, including 1 microRNA, 1 long non-coding RNA, and 6 messenger RNAs. Decreased survival was associated with CESC patients being in the high-risk group stratified by NPI. The NPI was an independent predictor for CESC patient prognosis and it outperformed the known clinicopathological characteristics, microRNA-only signature, gene-only signature, and previously identified microRNA and gene signatures. Function and pathway enrichment analysis revealed that the identified prognostic RNAs were mainly involved in angiogenesis. In conclusion, we proposed a transcriptomic signature for CESC prognosis and it may be useful for effective clinical risk management of CESC patients. Moreover, RNAs in the transcriptomic signature provided clues for downstream experimental validation and mechanism exploration. |
| 收录类别 | SCI |
| WOS关键词 | TUMOR ANGIOGENESIS ; BINDING PROTEIN ; GROWTH-FACTOR ; CANCER ; METASTASIS ; GENE ; ZIC2 ; PHD2 ; SUPPRESSOR ; TARGET |
| WOS研究方向 | Genetics & Heredity |
| WOS类目 | Genetics & Heredity |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000454936100001 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2558211 |
| 专题 | 寒区旱区环境与工程研究所 |
| 通讯作者 | Xiong, Jie |
| 作者单位 | 1.Cent S Univ, Xiangya Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Changsha, Hunan, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Dept Computat Phys, Lanzhou, Gansu, Peoples R China 3.Changsha Cent Hosp, Dept Gynaecol & Obstet, Changsha, Hunan, Peoples R China 4.Hunan Prov Peoples Hosp, Dept Operat 1, Changsha, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiong, Jie,Guo, Shengyu,Bing, Zhitong,et al. A Comprehensive RNA Expression Signature for Cervical Squamous Cell Carcinoma Prognosis[J]. FRONTIERS IN GENETICS,2019,9:12. |
| APA | Xiong, Jie,Guo, Shengyu,Bing, Zhitong,Su, Yanlin,&Guo, Le.(2019).A Comprehensive RNA Expression Signature for Cervical Squamous Cell Carcinoma Prognosis.FRONTIERS IN GENETICS,9,12. |
| MLA | Xiong, Jie,et al."A Comprehensive RNA Expression Signature for Cervical Squamous Cell Carcinoma Prognosis".FRONTIERS IN GENETICS 9(2019):12. |
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