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	Radiation induces premature chromatid separation via the miR-142-3p/Bod1 pathway in carcinoma cells
	Pan, Dong1,2,3; Du, Yarong1,2; Ren, Zhenxin1,2; Chen, Yaxiong1,2; Li, Xiaoman1,2,3; Wang, Jufang1,2; Hu, Burong1,2,4,5
刊名	ONCOTARGET
	2016-09-13
卷号	7期号:37页码:60432-60445
关键词	radiation premature chromatid separation miR-142-3p Bod1 radiosensitivity
ISSN号	1949-2553
DOI	10.18632/oncotarget.11080
通讯作者	Hu, Burong(hubr@impcas.ac.cn)
英文摘要	Radiation-induced genomic instability plays a vital role in carcinogenesis. Bod1 is required for proper chromosome biorientation, and Bod1 depletion increases premature chromatid separation. MiR-142-3p influences cell cycle progression and inhibits proliferation and invasion in cervical carcinoma cells. We found that radiation induced premature chromatid separation and altered miR-142-3p and Bod1 expression in 786-O and A549 cells. Overexpression of miR-142-3p increased premature chromatid separation and G2/M cell cycle arrest in 786-O cells by suppressing Bod1 expression. We also found that either overexpression of miR-142-3p or knockdown of Bod1 sensitized 786-O and A549 cells to X-ray radiation. Overexpression of Bod1 inhibited radiation-and miR-142-3p-induced premature chromatid separation and increased resistance to radiation in 786-O and A549 cells. Taken together, these results suggest that radiation alters miR-142-3p and Bod1 expression in carcinoma cells, and thus contributes to early stages of radiation-induced genomic instability. Combining ionizing radiation with epigenetic regulation may help improve cancer therapies.
收录类别	SCI
WOS关键词	PROTEIN PHOSPHATASE 2A ; INDUCED GENOMIC INSTABILITY ; STRAND BREAK REPAIR ; IONIZING-RADIATION ; CANCER CELLS ; INDUCED APOPTOSIS ; CERVICAL-CANCER ; MECHANISMS ; PROLIFERATION ; EXPRESSION
WOS研究方向	Oncology ; Cell Biology
WOS类目	Oncology ; Cell Biology
语种	英语
出版者	IMPACT JOURNALS LLC
WOS记录号	WOS:000387153900126
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2557999
专题	寒区旱区环境与工程研究所
通讯作者	Hu, Burong
作者单位	1.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Key Lab Space Radiobiol Gansu Prov, Lanzhou, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Soochow Univ, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst, Suzhou, Jiangsu, Peoples R China 5.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Pan, Dong,Du, Yarong,Ren, Zhenxin,et al. Radiation induces premature chromatid separation via the miR-142-3p/Bod1 pathway in carcinoma cells[J]. ONCOTARGET,2016,7(37):60432-60445.
APA	Pan, Dong.,Du, Yarong.,Ren, Zhenxin.,Chen, Yaxiong.,Li, Xiaoman.,...&Hu, Burong.(2016).Radiation induces premature chromatid separation via the miR-142-3p/Bod1 pathway in carcinoma cells.ONCOTARGET,7(37),60432-60445.
MLA	Pan, Dong,et al."Radiation induces premature chromatid separation via the miR-142-3p/Bod1 pathway in carcinoma cells".ONCOTARGET 7.37(2016):60432-60445.

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