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	Comparative Profiling of MicroRNAs Reveals the Underlying Toxicological Mechanism in Mice Testis Following Carbon Ion Radiation
	He, Yuxuan1; Zhang, Yong1; Li, Hongyan2; Zhang, Hong2; Li, Zongshuai1; Xiao, Longfei1; Hu, Junjie1; Ma, Youji1; Zhang, Quanwei1; Zhao, Xingxu1
刊名	DOSE-RESPONSE
	2018-06-20
卷号	16期号:2页码:12
关键词	heavy ion radiation miRNAs testis
ISSN号	1559-3258
DOI	10.1177/1559325818778633
通讯作者	Zhao, Xingxu(zhaoxx@gsau.edu.cn)
英文摘要	This study investigated the toxicity of heavy ion radiation to mice testis by microRNA (miRNA) sequencing and bioinformatics analyses. Testicular indices and histology were measured following enterocoelia irradiation with a 2 Gy carbon ion beam, with the testes exhibiting the most serious injuries at 4 weeks after carbon ion radiation (CIR) exposure. Illumina sequencing technology was used to sequence small RNA libraries of the control and irradiated groups at 4 weeks after CIR. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses implicated differential miRNAs in the regulation of target genes involved in metabolism, development, and reproduction. Here, 8 miRNAs, including miR-34c-5p, miR-138, and 6 let-7 miRNA family members previously reported in testis after radiation, were analyzed by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) to validate miRNA sequencing data. The differentially expressed miRNAs described here provided a novel perspective for the role of miRNAs in testis toxicity following CIR.
收录类别	SCI
WOS关键词	UP-REGULATION ; SPERMATOGONIAL DIFFERENTIATION ; EXPRESSION PROFILES ; MALE-INFERTILITY ; CANCER-PATIENTS ; CELL APOPTOSIS ; SPERMATOGENESIS ; IRRADIATION ; SPERM ; ONCOFERTILITY
WOS研究方向	Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging ; Toxicology
WOS类目	Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging ; Toxicology
语种	英语
出版者	SAGE PUBLICATIONS INC
WOS记录号	WOS:000435970700001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2557803
专题	寒区旱区环境与工程研究所
通讯作者	Zhao, Xingxu
作者单位	1.Gansu Agr Univ, Coll Vet Med, Lanzhou 730070, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou, Gansu, Peoples R China
推荐引用方式 GB/T 7714	He, Yuxuan,Zhang, Yong,Li, Hongyan,et al. Comparative Profiling of MicroRNAs Reveals the Underlying Toxicological Mechanism in Mice Testis Following Carbon Ion Radiation[J]. DOSE-RESPONSE,2018,16(2):12.
APA	He, Yuxuan.,Zhang, Yong.,Li, Hongyan.,Zhang, Hong.,Li, Zongshuai.,...&Zhao, Xingxu.(2018).Comparative Profiling of MicroRNAs Reveals the Underlying Toxicological Mechanism in Mice Testis Following Carbon Ion Radiation.DOSE-RESPONSE,16(2),12.
MLA	He, Yuxuan,et al."Comparative Profiling of MicroRNAs Reveals the Underlying Toxicological Mechanism in Mice Testis Following Carbon Ion Radiation".DOSE-RESPONSE 16.2(2018):12.

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